{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:39:18Z","timestamp":1774899558004,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370327"],"award-info":[{"award-number":["81370327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>The concentrations of \u03b2<jats:sub>1<\/jats:sub>\u2010adrenergic receptor and M<jats:sub>2<\/jats:sub>\u2010muscarinic receptor autoantibodies in hypertrophic cardiomyopathy (HCM) patients and the relationship between the cardiac autoantibodies and clinical manifestations of HCM have rarely been reported.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>We found that the concentrations of the two autoantibodies in HCM patients were significantly higher than those in control subjects. Furthermore, we found that the concentrations of the two autoantibodies could reflect myocardial injury and diastolic dysfunction in HCM patients to some extent and might be involved in the occurrence of arrhythmia. These findings might be valuable in exploration of the mechanisms of occurrence and progression of HCM.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Increasing attention is being given to the role of immunological mechanisms in the development of heart failure. The purpose of this study was to investigate the concentration of serum \u03b2<jats:sub>1<\/jats:sub>\u2010adrenergic receptor autoantibody (\u03b2<jats:sub>1<\/jats:sub>\u2010AAb) and M<jats:sub>2<\/jats:sub>\u2010muscarinic receptor autoantibody (M<jats:sub>2<\/jats:sub>\u2010AAb) in patients with hypertrophic cardiomyopathy (HCM), and the relationship between \u03b2<jats:sub>1<\/jats:sub>\u2010AAb, M<jats:sub>2<\/jats:sub>\u2010AAb and clinical indices. One hundred and thirty\u2010four patients with HCM were recruited consecutively into the HCM group. Forty healthy subjects were assigned as the normal controls (NCs). Serum samples were collected to measure the concentrations of \u03b2<jats:sub>1<\/jats:sub>\u2010AAb and M<jats:sub>2<\/jats:sub>\u2010AAb by enzyme\u2010linked immunosorbent assay. The clinical data of HCM patients were collected. The serum concentrations of \u03b2<jats:sub>1<\/jats:sub>\u2010AAb and M<jats:sub>2<\/jats:sub>\u2010AAb of HCM patients were significantly higher than those of NCs. In HCM patients, those with a left atrial diameter \u226550\u00a0mm or moderate\u2010to\u2010severe mitral regurgitation had significantly higher concentrations of the two autoantibodies. Patients with a history of syncope had higher concentrations of \u03b2<jats:sub>1<\/jats:sub>\u2010AAb. Female patients and patients with a family history of sudden cardiac death or atrial fibrillation had higher concentrations of M<jats:sub>2<\/jats:sub>\u2010AAb. Maximal wall thickness, interventricular septum thickness and resting left ventricular outflow tract gradient were positively correlated with log\u00a0\u03b2<jats:sub>1<\/jats:sub>\u2010AAb or log\u00a0M<jats:sub>2<\/jats:sub>\u2010AAb in HCM patients. In conclusion, the serum concentrations of \u03b2<jats:sub>1<\/jats:sub>\u2010AAb and M<jats:sub>2<\/jats:sub>\u2010AAb of HCM patients were significantly higher than those of NCs. Being female, syncope, a family history of sudden death, atrial fibrillation, left atrial diameter \u226550\u00a0mm, moderate\u2010to\u2010severe mitral regurgitation, maximal wall thickness, interventricular septum thickness and resting left ventricular outflow tract gradient may affect the concentrations of the two autoantibodies.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep088263","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T06:54:34Z","timestamp":1575615274000},"page":"522-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The relationship between \u03b2<sub>1<\/sub>\u2010adrenergic and M<sub>2<\/sub>\u2010muscarinic receptor autoantibodies and hypertrophic cardiomyopathy"],"prefix":"10.1113","volume":"105","author":[{"given":"Xin","family":"Duan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease Department of Cardiology Fuwai 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