{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:20:07Z","timestamp":1771658407615,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560301"],"award-info":[{"award-number":["81560301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81160012"],"award-info":[{"award-number":["81160012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>The acute hypoxic compensatory reaction is based on haemodynamic changes, and \u03b2\u2010adrenoceptors are involved in haemodynamic regulation. What is the role of \u03b2\u2010adrenoceptors in haemodynamics during hypoxic exposure?<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Activation of \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptors attenuates the increase in pulmonary artery pressure during hypoxic exposure. This compensatory reaction activated by \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptors during hypoxic stress is very important to maintain the activities of normal life.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The acute hypoxic compensatory reaction is accompanied by haemodynamic changes. We monitored the haemodynamic changes in rats undergoing acute hypoxic stress and applied antagonists of \u03b2\u2010adrenoceptor (\u03b2\u2010ARs) subtypes to reveal the regulatory role of \u03b2\u2010ARs on haemodynamics. Sprague\u2013Dawley rats were randomly divided into control, atenolol (\u03b2<jats:sub>1<\/jats:sub>\u2010AR antagonist), ICI\u00a0118,551 (\u03b2<jats:sub>2<\/jats:sub>\u2010AR antagonist) and propranolol (non\u2010selective \u03b2\u2010AR antagonist) groups. Rats were continuously recorded for changes in haemodynamic indexes for 10\u00a0min after administration. Then, a hypoxic ventilation experiment [15% O<jats:sub>2<\/jats:sub>, 2200 m a.sl., 582 mmHg (0.765 Pa), <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12827-math-0001.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12827:eph12827-math-0001\"\/> 87.3 mmHg; Xining, China] was conducted, and the indexes were monitored for 5\u00a0min after induction of hypoxia. Plasma catecholamine concentrations were also measured. We found that, during normoxia, the mean arterial pressure, heart rate, ascending aortic blood flow and pulmonary artery pressure were reduced in the propranolol and atenolol groups. Catecholamine concentrations were increased significantly in the atenolol group compared with the control group. During hypoxia, mean arterial pressure and total peripheral resistance were decreased in the control, propranolol and ICI\u00a0118,551 groups. Pulmonary arterial pressure and pulmonary vascular resistance were increased in the propranolol and ICI\u00a0118,551 groups. During hypoxia, catecholamine concentrations were increased significantly in the control group, but decreased in \u03b2\u2010AR antagonist groups. In conclusion, the \u03b2<jats:sub>2<\/jats:sub>\u2010AR is involved in regulation of pulmonary haemodynamics in the acute hypoxic compensatory reaction, and the activation of \u03b2<jats:sub>2<\/jats:sub>\u2010ARs attenuates the increase in pulmonary arterial pressure during hypoxic stress. This compensatory reaction activated by \u03b2<jats:sub>2<\/jats:sub>\u2010ARs during hypoxic stress is very important to maintain activities of normal life.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep088669","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T12:54:16Z","timestamp":1595595256000},"page":"1660-1668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of \u03b2\u2010adrenoceptor activation on haemodynamics during hypoxic stress in rats"],"prefix":"10.1113","volume":"105","author":[{"given":"Qiaorong","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Basic Medicine Medical College of Qinghai University  No.16 kunlun road Xining Qinghai 810001 China"},{"name":"Pathophysiology Laboratory The Key Laboratory of Science and Technology for High Altitude Medicine  No.16 kunlun road Xining Qinghai 810001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Medical College of Qinghai University  No.16 kunlun road Xining Qinghai 810001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Weinan Central Hospital  Shengli street Weinan Shaanxi 714000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Medical College of Qinghai University  No.16 kunlun road Xining Qinghai 810001 China"},{"name":"Pathophysiology Laboratory The Key Laboratory of Science and Technology for High Altitude Medicine  No.16 kunlun road Xining Qinghai 810001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengzhu","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Medical College of Qinghai University  No.16 kunlun road Xining Qinghai 810001 China"},{"name":"Pathophysiology Laboratory The Key Laboratory of Science and Technology for High Altitude Medicine  No.16 kunlun road Xining Qinghai 810001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhouyang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Medical College of Qinghai University  No.16 kunlun road Xining Qinghai 810001 China"},{"name":"Pathophysiology Laboratory The Key Laboratory of Science and Technology for High Altitude Medicine  No.16 kunlun road Xining Qinghai 810001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Medical College of Qinghai University  No.16 kunlun road Xining Qinghai 810001 China"},{"name":"Pathophysiology Laboratory The Key Laboratory of Science and Technology for High Altitude Medicine  No.16 kunlun road Xining Qinghai 810001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Medical College of Qinghai University  No.16 kunlun road Xining Qinghai 810001 China"},{"name":"Pathophysiology Laboratory The Key Laboratory of Science and Technology for High Altitude Medicine  No.16 kunlun road Xining Qinghai 810001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2012.1117"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00532-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01167.2010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00754.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.650796"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)02306-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.04.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb02436.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00860"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00509.2018"},{"key":"e_1_2_9_12_1","first-page":"14","article-title":"Adrenergic regulation of the mammalian heart","volume":"60","author":"Chottov\u00e1 D. 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