{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:08:00Z","timestamp":1747188480650,"version":"3.40.5"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>What are the characteristics of cerebral blood flow (CBF) regulation following a single SCUBA dive to a depth of 18\u00a0m sea water with a 47\u00a0min bottom time.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Acute alterations in CBF regulation at rest, including extra\u2010cranial vasodilatation, reductions in shear patterns and elevations in intra\u2010cranial blood velocity were observed at rest following a single SCUBA dive.<\/jats:p>\n<jats:p>These subtle changes in CBF regulation did not translate into any functional changes in cerebrovascular reactivity to hypoxia or hyperoxia, or neurovascular coupling following a single SCUBA dive.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Reductions in vascular function during a SCUBA dive \u2013 due to hyperoxia\u2010induced oxidative stress, arterial and venous gas emboli and altered endothelial integrity \u2013 may also extend to the cerebrovasculature following return to the surface. This study aimed to characterize cerebral blood flow (CBF) regulation following a single SCUBA dive to a depth of 18\u00a0m sea water with a 47\u00a0min bottom time. Prior to and following the dive, participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) completed (1) resting CBF in the internal carotid (ICA) and vertebral (VA) arteries (duplex ultrasound) and intra\u2010cranial blood velocity (<jats:italic>v<\/jats:italic>) of the middle and posterior cerebral arteries (MCA<jats:italic>v<\/jats:italic> and PCA<jats:italic>v<\/jats:italic>, respectively) (transcranial Doppler ultrasound); (2) cerebrovascular reactivity to acute poikilocapnic hypoxia (i.e. <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12810-math-0001.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12810:eph12810-math-0001\"\/>, 0.10) and hyperoxia (i.e. <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12810-math-0002.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12810:eph12810-math-0002\"\/>, 1.0); and (3) neurovascular coupling (NVC; regional CBF response to local increases in cerebral metabolism). Global CBF, cerebrovascular reactivity to hypoxia and hyperoxia, and NVC were unaltered following a SCUBA dive (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05); however, there were subtle changes in other cerebrovascular metrics post\u2010dive, including reductions in ICA (\u221213\u00a0\u00b1\u00a08%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and VA (\u221211\u00a0\u00b1\u00a014%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021) shear rate, lower ICA<jats:italic>v<\/jats:italic> (\u221210\u00a0\u00b1\u00a09%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008) and VA<jats:italic>v<\/jats:italic> (\u22129\u00a0\u00b1\u00a014%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028), increases in ICA diameter (+4\u00a0\u00b1\u00a05%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.017) and elevations in PCA<jats:italic>v<\/jats:italic> (+10\u00a0\u00b1\u00a019%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.047). Although we observed subtle alterations in CBF regulation at rest, these changes did not translate into any functional changes in cerebrovascular reactivity to hypoxia or hyperoxia, or NVC. Whether prolonged exposure to hyperoxia and hyperbaria during longer, deeper, colder and\/or repetitive SCUBA dives would provoke changes to the cerebrovasculature requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep088746","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T10:53:39Z","timestamp":1593773619000},"page":"1540-1549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alterations in resting cerebrovascular regulation do not affect reactivity to hypoxia, hyperoxia or neurovascular coupling following a SCUBA dive"],"prefix":"10.1113","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6072-7277","authenticated-orcid":false,"given":"Hannah G.","family":"Caldwell","sequence":"first","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health School of Health and Exercise Sciences University of British Columbia  Okanagan Kelowna Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-0059","authenticated-orcid":false,"given":"Ryan L.","family":"Hoiland","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health School of Health and Exercise Sciences University of British Columbia  Okanagan Kelowna Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto F.","family":"Barak","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Novi Sad  Novi Sad Serbia"},{"name":"Faculty of Sports and Physical Education University of Novi Sad  Novi Sad Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Mijacika","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Split School of Medicine  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel S.","family":"Burma","sequence":"additional","affiliation":[{"name":"Sport Injury Prevention Research Centre Faculty of Kinesiology University of Calgary  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017deljko","family":"Duji\u0107","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Split School of Medicine  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N.","family":"Ainslie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health School of Health and Exercise Sciences University of British Columbia  Okanagan Kelowna Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00854.2014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2010.00974.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-017-0135-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00412.2017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-103589"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000625"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-013-2600-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0223OC"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2000.0313"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199111060-00003"},{"key":"e_1_2_9_12_1","first-page":"581","article-title":"Cardiovascular and thermal responses to SCUBA diving","volume":"28","author":"Doubt T. 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