{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:25:15Z","timestamp":1792646715244,"version":"4.5.0"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Does peripheral non\u2010invasive focused ultrasound targeted to the celiac plexus improve inflammatory bowel disease?<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Peripheral non\u2010invasive focused ultrasound targeted to the celiac plexus in a rat model of ulcerative colitis improved stool consistency and reduced stool bloodiness, which coincided with a longer and healthier colon than in animals without focused ultrasound treatment. The findings suggest that this novel neuromodulatory technology could serve as a plausible therapeutic approach for improving symptoms of inflammatory bowel disease.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Individuals suffering from inflammatory bowel disease (IBD) experience significantly diminished quality of life. Here, we aim to stimulate the celiac plexus with non\u2010invasive peripheral focused ultrasound (FUS) to modulate the enteric cholinergic anti\u2010inflammatory pathway. This approach may have clinical utility as an efficacious IBD treatment given the non\u2010invasive and targeted nature of this therapy. We employed the dextran sodium sulfate (DSS) model of colitis, administering lower (5%) and higher (7%) doses to rats in drinking water. FUS on the celiac plexus administered twice a day for 12 consecutive days to rats with severe IBD improved stool consistency scores from 2.2\u00a0\u00b1\u00a01 to 1.0\u00a0\u00b1\u00a00.0 with peak efficacy on day 5 and maximum reduction in gross bleeding scores from 1.8\u00a0\u00b1\u00a00.8 to 0.8\u00a0\u00b1\u00a00.8 on day 6. Similar improvements were seen in animals in the low dose DSS group, who received FUS only once daily for 12\u00a0days. Moreover, animals in the high dose DSS group receiving FUS twice daily maintained colon length (17.7\u00a0\u00b1\u00a02.5\u00a0cm), while rats drinking DSS without FUS exhibited marked damage and shortening of the colon (13.8\u00a0\u00b1\u00a00.6\u00a0cm) as expected. Inflammatory cytokines such as interleukin (IL)\u20101\u03b2, IL\u20106, IL\u201017, tumour necrosis factor\u2010\u03b1 and interferon\u2010\u03b3 were reduced with DSS but coincided with control levels after FUS, which is plausibly due to a loss of colon crypts in the former and healthier crypts in the latter. Lastly, overall, these results suggest non\u2010invasive FUS of peripheral ganglion can deliver precision therapy to improve IBD symptomology.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep088848","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T10:23:50Z","timestamp":1611915830000},"page":"1038-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Non\u2010invasive peripheral focused ultrasound neuromodulation of the celiac plexus ameliorates symptoms in a rat model of inflammatory bowel disease"],"prefix":"10.1113","volume":"106","author":[{"given":"Kainat","family":"Akhtar","sequence":"first","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zall","family":"Hirschstein","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Stefanelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Iannilli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Barenboim","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Balkaya","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyah","family":"Audil","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliyahu M.","family":"Kochman","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyee","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saisree","family":"Mikkilineni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanel","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"William","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Disease Albany Medical College  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Fan","sequence":"additional","affiliation":[{"name":"General Electric Global Research Center  Niskayuna NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Cotero","sequence":"additional","affiliation":[{"name":"General Electric Global Research Center  Niskayuna NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Ashe","sequence":"additional","affiliation":[{"name":"General Electric Global Research Center  Niskayuna NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Puleo","sequence":"additional","affiliation":[{"name":"General Electric Global Research Center  Niskayuna NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Jen","family":"Kao","sequence":"additional","affiliation":[{"name":"General Electric Global Research Center  Niskayuna NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-7311","authenticated-orcid":false,"given":"Damian S.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; Experimental Therapeutics Albany Medical College  Albany NY USA"},{"name":"Department of Neurology Albany Medical Center  Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020888"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.04.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.08.024"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.01.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.01.014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12792"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013070"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.046"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087785"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1525s104"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2058738419843367"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08750-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6542a3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.08.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/493012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025058"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i33.6016"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082118"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013010084"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271537"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270818"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP085299"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13676"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.52"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.01.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2017.17.1.25"},{"key":"e_1_2_9_29_1","first-page":"3678","article-title":"Investigating intestinal inflammation in DSS\u2010induced model of IBD","author":"Kim J. J.","year":"2012","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.06.005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061216"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30526-2"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00298.2018"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2013.12.007"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.5688\/aj710478"},{"key":"e_1_2_9_36_1","first-page":"s51","article-title":"Report: economic implications of inflammatory bowel disease and its management","volume":"22","author":"Mehta F.","year":"2016","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.10.007"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12718"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4137\/CGast.S12731"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2862::AID-ART474>3.0.CO;2-W"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13288"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7754-3"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1209614"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.06.033"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2015.20.4.260"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.189"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402177"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2583-x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00418"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00418"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90045-0"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a034215"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209985"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2017.07.010"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4280"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes375"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000078"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069424"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00094.2013"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan8162"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00208.2019"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01339"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13163"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.044"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP088848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP088848","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP088848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T17:48:04Z","timestamp":1693590484000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP088848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1113\/EP088848"],"URL":"https:\/\/doi.org\/10.1113\/ep088848","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"2020-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}