{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:09:35Z","timestamp":1792613375768,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T00:00:00Z","timestamp":1597449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001305","name":"Christopher and Dana Reeve Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005191","name":"Craig H. Neilsen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Spinal cord injury results in paralysis and deleterious neuromuscular and autonomic adaptations. Lumbosacral epidural stimulation can modulate motor and\/or autonomic functions. Does long\u2010term epidural stimulation for normalizing cardiovascular function affect leg muscle properties?<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Leg lean mass increased after long\u2010term epidural stimulation for cardiovascular function, which was applied in the sitting position and did not activate the leg muscles. Leg muscle strength and fatigue resistance, assessed in a subgroup of individuals, also increased. These adaptations might support interventions for motor recovery and warrant further mechanistic investigation.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Chronic motor complete spinal cord injury (SCI) results in paralysis and deleterious neuromuscular and autonomic adaptations. Paralysed muscles demonstrate atrophy, loss of force and increased fatigability. Also, SCI\u2010induced autonomic impairment results in persistently low resting blood pressure and heart rate, among other features. We previously reported that spinal cord epidural stimulation (scES) optimized for cardiovascular (CV) function (CV\u2010scES), which is applied in sitting position and does not activate the leg muscles, can maintain systolic blood pressure within a normotensive range during quiet sitting and during orthostatic stress. In the present study, dual\u2010energy X\u2010ray absorptiometry collected from six individuals with chronic clinically motor complete SCI demonstrated that 88\u00a0\u00b1\u00a011 sessions of CV\u2010scES (7\u00a0days\u00a0week<jats:sup>\u22121<\/jats:sup>; 2\u00a0h\u00a0day<jats:sup>\u22121<\/jats:sup> in four individuals and 5\u00a0h\u00a0day<jats:sup>\u22121<\/jats:sup> in two individuals) over a period of \u223c6\u00a0months significantly increased lower limb lean mass (by 0.67\u00a0\u00b1\u00a00.39\u00a0kg or 9.4\u00a0\u00b1\u00a08.1%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Additionally, muscle strength and fatigability data elicited by neuromuscular electrical stimulation in three of these individuals demonstrated a general increase (57\u00a0\u00b1\u00a0117%) in maximal torque output (between 2 and 44\u00a0N\u00a0m in 14 of the 17 muscle groups tested overall) and torque\u2013time integral during intermittent, fatiguing contractions (63\u00a0\u00b1\u00a071%; between 7 and 230% in 16 of the 17 muscle groups tested overall). In contrast, whole\u2010body mass and composition did not change significantly. In conclusion, long\u2010term use of CV\u2010scES can have a significant impact on lower limb muscle properties after chronic motor complete SCI.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep088876","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T15:22:37Z","timestamp":1596554557000},"page":"1684-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Epidural stimulation for cardiovascular function increases lower limb lean mass in individuals with chronic motor complete spinal cord injury"],"prefix":"10.1113","volume":"105","author":[{"given":"Bonnie","family":"Legg Ditterline","sequence":"first","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville KY USA"},{"name":"Department of Neurological Surgery University of Louisville  Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Harkema","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville KY USA"},{"name":"Department of Neurological Surgery University of Louisville  Louisville KY USA"},{"name":"Frazier Rehabilitation Institute University of Louisville Health  Louisville KY USA"},{"name":"Department of Bioengineering University of Louisville  Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Willhite","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Stills","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center University of Louisville  Louisville KY 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