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Although upper\u2010body exercise appears an effective strategy to improve some of these outcomes, the effectiveness of high\u2010intensity interval training (HIIT) has yet to be determined for this population. Therefore, a randomized controlled trial will be conducted to determine the effectiveness of a 6\u00a0week home\u2010based upper\u2010body HIIT intervention on biomarkers of cardiometabolic health in persons with spinal cord injury, in comparison to a control (CON) group. We will recruit 40 individuals with chronic (&gt;1 year post\u2010injury) paraplegia (spinal cord lesion between the second thoracic and second lumbar vertebrae), aged between 18 and 65\u00a0years. After baseline testing, participants will be assigned randomly, using a 2:1 allocation, to the home\u2010based exercise intervention (HIIT, <jats:italic>n<\/jats:italic> = 26) or control group (CON, <jats:italic>n<\/jats:italic> = 14). The HIIT intervention will consist of 30 min of arm crank\u2010based HIIT (60 s intervals at 80\u201390% peak heart rate) four times per week. Participants in the CON group will be asked to maintain their habitual diet and physical activity patterns over the study period. Baseline and follow\u2010up assessments will be made for determination of body composition, postprandial glycaemic control, fasting blood lipids and systemic inflammation, aerobic capacity, physical activity and energy intake, resting metabolic rate, resting blood pressure, and subjective measures of health and well\u2010being. ClinicalTrials.gov, ID: NCT04397250. Registered on 21 May 2020.<\/jats:p>","DOI":"10.1113\/ep089110","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T14:43:03Z","timestamp":1613659383000},"page":"1159-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of high\u2010intensity interval training on cardiometabolic component risks in persons with paraplegia: Protocol for a randomized controlled trial"],"prefix":"10.1113","volume":"106","author":[{"given":"Matthew T.","family":"Farrow","sequence":"first","affiliation":[{"name":"Centre for Clinical Rehabilitation and Exercise Medicine (CREM) Department for Health University of Bath  Bath UK"},{"name":"Centre for Nutrition and Exercise Metabolism (CNEM) Department for Health University of Bath  Bath UK"},{"name":"Centre for the Analysis of Motion Entertainment Research and Applications (CAMERA) University of Bath  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Maher","sequence":"additional","affiliation":[{"name":"Centre for Clinical Rehabilitation and Exercise Medicine (CREM) Department for Health University of Bath  Bath UK"},{"name":"Centre for Nutrition and Exercise Metabolism (CNEM) Department for Health University of Bath  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Thompson","sequence":"additional","affiliation":[{"name":"Centre for Clinical Rehabilitation and Exercise Medicine (CREM) Department for Health University of Bath  Bath UK"},{"name":"Centre for Nutrition and Exercise Metabolism (CNEM) Department for Health University of Bath  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-7603","authenticated-orcid":false,"given":"James L. 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