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We report unprecedented rapid changes (30\u00a0min) in ECG, blood pressure and various arterial blood analyses with this new model, providing a solid foundation for future experiments in this field.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>A variety of animal models have been proposed to study hyperkalaemia, but most of them have meaningful limitations when the goal is to study the effect of potassium overload on healthy kidneys. In this study, we aimed to introduce a new approach for induction of hyperkalaemia in a reliable and reproducible animal model. We used intragastric administration of potassium chloride [KCl 2.3\u00a0M, 10\u00a0ml\/(kg body weight)] to male Holtzman rats (300\u2013350\u00a0g) to induce hyperkalaemia. The results showed that this potassium load can temporarily overwhelm the renal and extrarenal handling of this ion, causing an acute and severe hyperkalaemia that can be useful to study the effect of potassium imbalance in a variety of scenarios. Severe hyperkalaemia (&gt;8\u00a0meqiv\/l) and very profound ECG alterations, characterized by lengthening waves and intervals, were seen as early as 30\u00a0min after intragastric administration of KCl in rats. In addition, a transient increase in arterial blood pressure and time\u2010dependent bradycardia were also seen after the KCl administration. No metabolic acidosis was present in the animals, and the potassium ion did not increase proportionally to chloride ion in the blood, leading to an increased anion gap. In conclusion, the results suggest that intragastric KCl loading is a reliable model to promote rapid and severe hyperkalaemia that can be used for further research on this topic.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep089356","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T16:50:12Z","timestamp":1614703812000},"page":"1263-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Electrocardiographic changes in the acute hyperkalaemia produced by intragastric KCl load in rats"],"prefix":"10.1113","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-0435","authenticated-orcid":false,"given":"Frederico","family":"Fazan","sequence":"first","affiliation":[{"name":"Araraquara School of Dentistry S\u00e3o Paulo State University  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Sim\u00f5es de 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