{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:01:11Z","timestamp":1769914871899,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Young plasma contains several rejuvenating factors that exert beneficial effects in ageing and neurodegenerative diseases: can repeated transfusion of young plasma improve depressive behaviour in aged rats?<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Following chronic transfusion of young plasma, depressive behaviour was improved in the depression model of aged rats, which was associated with reduced apoptosis process in the prefrontal cortex.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Brain ageing alters brain responses to stress, playing an essential role in the pathophysiology of late\u2010life depression. Moreover, apoptotic activity is up\u2010regulated in the prefrontal cortex in ageing and stress\u2010related mood disorders. Considerable evidence suggests that factors in young blood could reverse age\u2010related dysfunctions in organs, especially in the brain. Therefore, this study investigated the effect of young plasma administration on depressive behaviours in aged rats exposed to chronic unpredictable mild stress (CUMS), with a focus on the apoptosis process. Young (3\u00a0months old) and aged (22\u00a0months old) male rats were randomly assigned into four groups: young control (YC), aged control (AC), aged rats subjected to CUMS (A+CUMS) and aged rats subjected to CUMS and treated with young plasma (A+CUMS+YP). In the A+CUMS and A+CUMS+YP groups, CUMS was used to generate the depression rat model. Moreover, the A+CUMS+YP group received pooled plasma (1\u00a0ml, intravenously), collected from young rats, three times per week for 4\u00a0weeks. Young plasma administration significantly improved CUMS\u2010induced depression\u2010like behaviours, including decreased sucrose consumption ratio, reduced locomotor activity and prolonged immobility time. Importantly, young plasma reduced neuronal apoptosis in the prefrontal cortex that was associated with reduced TUNEL\u2010positive cells and cleaved caspase\u20103 protein levels in the A+CUMS+YP compared with the A+CUMS group. Young plasma can partially improve the neuropathology of late\u2010life depression through the apoptotic signalling pathways.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep089415","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T04:56:01Z","timestamp":1621572961000},"page":"1621-1630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Young plasma administration mitigates depression\u2010like behaviours in chronic mild stress\u2010exposed aged rats by attenuating apoptosis in prefrontal cortex"],"prefix":"10.1113","volume":"106","author":[{"given":"Arshad","family":"Ghaffari\u2010Nasab","sequence":"first","affiliation":[{"name":"Aging Research Institute Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Badalzadeh","sequence":"additional","affiliation":[{"name":"Aging Research Institute Tabriz University 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