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Although exercise is a well\u2010established approach to treat\/prevent cardiovascular diseases, its effects on iron overload are not known.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What is the main finding and its importance?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>Moderate\u2010intensity aerobic training had benefits in a rodent model of iron\u2010overload cardiomyopathy by improving the antioxidant capacity of the heart. After further confirmation by translational and clinical studies, we should consider using this non\u2010pharmacological, highly accessible and easily executable adjuvant approach allied to other therapies to improve the quality of life of iron\u2010overloaded patients.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Iron is an essential micronutrient for several life processes, but its excess can damage organs owing to oxidative stress, with cardiomyopathy being the leading cause of death in iron\u2010overloaded patients. Although exercise has long been considered as a cardioprotective tool, its effects on iron overload are not known. This study was designed to investigate the effects of moderate\u2010intensity aerobic training in rats previously submitted to chronic iron overload. Wistar rats received i.p. injections of iron dextran (100\u00a0mg\/kg, 5\u00a0days\/week for 4\u00a0weeks); thereafter, the rats were kept sedentary or exercised (60\u00a0min\/day, progressive aerobic training, 60\u201370% of maximal speed, 5\u00a0days\/week on a treadmill) for 8\u00a0weeks. At the end of the experimental period, haemodynamics were recorded and blood samples, livers and hearts harvested. Myocardial mechanics of papillary muscles were assessed\n                      <jats:italic>in vitro<\/jats:italic>\n                      , and cardiac remodelling was evaluated by histology and immunoblotting. Iron overload led to liver iron deposition, liver fibrosis and increased serum alanine aminotransferase and aspartate aminotransferase. Moreover, cardiac iron accumulation was accompanied by impaired myocardial mechanics, increased cardiac collagen type\u00a0I and lipid peroxidation (TBARS), and release of creatine phosphokinase\u2010MB to the serum. Although exercise did not influence iron levels, tissue injury markers were significantly reduced. Likewise, myocardial contractility and inotropic responsiveness were improved in exercised rats, in association with an increase in the endogenous antioxidant enzyme catalase. In conclusion, moderate\u2010intensity aerobic exercise was associated with attenuated oxidative stress and cardiac damage in a rodent model of iron overload, thereby suggesting its potential role as a non\u2010pharmacological adjuvant therapy for iron\u2010overload cardiomyopathy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/ep089429","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T23:18:50Z","timestamp":1624144730000},"page":"1772-1784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Moderate\u2010intensity aerobic training reduces cardiac damage attributable to experimental iron overload in rats"],"prefix":"10.1113","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5840-6906","authenticated-orcid":false,"given":"Renata Andrade","family":"\u00c1vila","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences Federal University of Espirito Santo  Vit\u00f3ria ES Brazil"},{"name":"Faculdades Integradas S\u00e3o Pedro (FAESA)  Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1527-1925","authenticated-orcid":false,"given":"Emilly Martinelli","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences Federal University of Espirito Santo  Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Mendes","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences Federal University of Espirito Santo  Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-0308","authenticated-orcid":false,"given":"Maiara","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Chemistry Federal University of Espirito Santo  Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3131-2467","authenticated-orcid":false,"given":"Andr\u00e9 Soares","family":"Leopoldo","sequence":"additional","affiliation":[{"name":"Department of Sports Federal University of Espirito Santo  Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-5093","authenticated-orcid":false,"given":"Maria Tereza W. 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