{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:08:28Z","timestamp":1747188508746,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>What is the role of the renal nerves in the development of obesity, hyperlipidaemia and hypertension during the long\u2010term feeding of a moderately high\u2010fat diet in male obesity\u2010prone rats?<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>The renal nerves play a prominent mediatory role, without influencing the establishment of visceral adiposity and atherogenic hyperlipidaemia, in the induction and progression of pressure natriuresis impairment and hypertension during the developmental period of diet\u2010induced obesity.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Feeding a moderately high\u2010fat (MHF) diet in male Sprague\u2013Dawley rats induces obesity, pressure natriuresis impairment and hypertension. This study investigated the role of the renal nerves in the impaired pressure natriuresis and hypertension caused by feeding a MHF diet. After collecting baseline data on day 0, 12 rats remained on a low\u2010fat diet (LF group) while the others were switched onto a MHF diet and diverged into obesity\u2010resistant (OR) or obesity\u2010prone (OP). After 4\u00a0weeks, half of the OR and OP rats underwent bilateral renal denervation (BRD) to generate four groups: OR, OR\/BRD, OP and OP\/BRD (<jats:italic>n\u00a0=\u00a0<\/jats:italic>12). During 10\u00a0weeks, body weight, obesity index, systolic pressure and renal excretory function were measured regularly. After 10\u00a0weeks, renal excretory responses to acute salt loading and renal autoregulation were evaluated. The OP and OP\/BRD groups had greater increases of body weight and obesity index during the dietary period compared to the other groups, and by week 10 their body weight (425.1\u00a0\u00b1\u00a07.2 and 411.9\u00a0\u00b1\u00a05.1\u00a0g) became considerably larger than that of the LF group (358.5\u00a0\u00b1\u00a06.2\u00a0g). Renal sodium excretion was reduced by \u223c20% at week 4 in the OP and OP\/BRD groups, while only the OP group had lower sodium excretion at weeks 6\u20138 and higher systolic pressure over weeks 5\u201310 than the other groups and its week 10 systolic pressure reached 138.1\u00a0\u00b1\u00a06.7 versus 123.6\u00a0\u00b1\u00a02.7\u00a0mmHg of the LF group. The OP group showed delayed renal excretory responses to salt loading with rightward and downward shifts in renal autoregulatory curves. Therefore, the renal nerves exert a main mediatory role in the development of pressure natriuresis impairment and hypertension as obesity is established due to the long\u2010term consumption of the MHF diet in male OP rats.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep089545","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T01:09:23Z","timestamp":1630631363000},"page":"2248-2261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bilateral renal denervation prevents the development of hypertension during diet\u2010induced obesity in male rats"],"prefix":"10.1113","volume":"106","author":[{"given":"Somayeh","family":"Nazari","sequence":"first","affiliation":[{"name":"Department of Physiology The Medical School Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Medicinal and Natural Products Chemistry Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Haghani","sequence":"additional","affiliation":[{"name":"Department of Physiology The Medical School Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-1512","authenticated-orcid":false,"given":"Seyed Mostafa Shid","family":"Moosavi","sequence":"additional","affiliation":[{"name":"Department of Physiology The Medical School Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Shiraz Nephro\u2010Urology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07993"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/865965"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-014-4072-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000532"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.44"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00633"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.727"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.4.1009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32831cbd5a"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303604"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.10.1.1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.113175"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S39739"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305697"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0145-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu048"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.03098"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5049\/EBP.2013.11.2.46"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000197"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12499"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1761.2007.01702.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.10.011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.185074"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.7922"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y10-098"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8802490"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1556\/APhysiol.101.2014.1.10"},{"key":"e_1_2_9_29_1","first-page":"83","volume-title":"Brenner and Rector's the kidney","author":"Munger K. 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