{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:11:43Z","timestamp":1791925903896,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV\u201017\u20100178"],"award-info":[{"award-number":["APVV\u201017\u20100178"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Artificial light at night decreases blood pressure and heart rate in rats. Are these changes in heart rate accompanied by changes in protein expression in the heart's left ventricle?<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Five weeks of artificial light at night affected protein expression in the heart's left ventricle in normotensive and hypertensive rats. Artificial light at night decreased expression of the sarco\/endoplasmic reticulum Ca<jats:sup>2+<\/jats:sup>\u2010ATPase, angiotensin II receptor type 1 and endothelin\u20101.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Artificial light at night (ALAN) affects the circadian rhythm of the heart rate in normotensive Wistar rats (WT) and spontaneously hypertensive rats (SHR) through the autonomic nervous system, which regulates the heart's activity through calcium handling, an important regulator in heart contractility. We analysed the expression of the sarco\/endoplasmic reticulum Ca<jats:sup>2+<\/jats:sup>\u2010ATPase (SERCA2) and other selected regulatory proteins involved in the regulation of heart contractility, angiotensin II receptor type 1 (AT<jats:sub>1<\/jats:sub>R), endothelin\u20101 (ET\u20101) and tyrosine hydroxylase (TH), in the left ventricle of the heart in WT and SHR after 2 and 5\u00a0weeks of ALAN with intensity 1\u20132\u00a0lx. Expression of SERCA2 was decreased in WT (control: 0.53\u00a0\u00b1\u00a00.07; ALAN: 0.46\u00a0\u00b1\u00a00.10) and SHR (control: 0.72\u00a0\u00b1\u00a00.18; ALAN: 0.56\u00a0\u00b1\u00a00.21) after 5\u00a0weeks of ALAN (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.067). Expression of AT<jats:sub>1<\/jats:sub>R was significantly decreased in WT (control: 0.51\u00a0\u00b1\u00a00.27; ALAN: 0.34\u00a0\u00b1\u00a00.20) and SHR (control: 0.38\u00a0\u00b1\u00a00.07; ALAN: 0.23\u00a0\u00b1\u00a00.09) after 2\u00a0weeks of ALAN (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028) and in SHR after 5\u00a0weeks of ALAN. Expression of ET\u20101 was decreased in WT (control: 0.51\u00a0\u00b1\u00a00.27; ALAN: 0.28\u00a0\u00b1\u00a00.12) and SHR (control: 0.54\u00a0\u00b1\u00a00.10; ALAN: 0.35\u00a0\u00b1\u00a00.23) after 5\u00a0weeks of ALAN (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015). ALAN did not affect the expression of TH in WT or SHR. In conclusion, ALAN suppressed the expression of SERCA2, AT<jats:sub>1<\/jats:sub>R and ET\u20101, which are important for the regulation of heart contractility, in a strain\u2010dependent pattern in both WT and SHR.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep089594","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T14:38:52Z","timestamp":1622903932000},"page":"1762-1771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Artificial light at night suppresses the expression of sarco\/endoplasmic reticulum Ca<sup>2+<\/sup>\u2010ATPase in the left ventricle of the heart in normotensive and hypertensive rats"],"prefix":"10.1113","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-5888","authenticated-orcid":false,"given":"Hana","family":"Sutovska","sequence":"first","affiliation":[{"name":"Department of Animal Physiology and Ethology Faculty of Natural Sciences, 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