{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:41:18Z","timestamp":1782819678402,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>We evaluated the effects of diabetes and exercise on lipopolysaccharide\u2010induced acute lung injury. By providing a comprehensive analysis of redox status, blood gases and histological parameters, we aimed to contribute to the ongoing debate in the literature.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What are the main findings and its importance?<\/jats:bold><\/jats:p>\n<jats:p>We demonstrated the preventive effect of exercise, but diabetes did not alter the severity of acute lung injury.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Acute lung injury (ALI) is a life\u2010threatening respiratory condition. Diabetes (DM) is a metabolic disease characterized by hyperglycaemia. There is an ongoing debate concerning whether there is a protective effect of diabetes in ALI. Exercise is a special type of physical activity that has numerous beneficial effects. The aim of our study was to investigate the effects of diabetes and exercise on the prognosis of ALI. Male Wistar albino rats were divided into two groups (sedentary and exercise). Both groups were divided into four subgroups: Control, ALI, DM, DM+ALI (<jats:italic>n<\/jats:italic>\u00a0=\u00a06 each). Diabetes was induced by injection of streptozotocin (50\u00a0mg\/kg i.p.). The maximal exercise capacity was determined with the incremental load test. Animals were exercised on a treadmill for 45\u00a0min at 70% of maximal exercise capacity, 5\u00a0days a week for 12\u00a0weeks. Acute lung injury was induced by intratracheal injection of lipopolysaccharide (100\u00a0\u03bcg\/100\u00a0g body weight) 24\u00a0h before the end of the experiment. We performed arterial blood gas analysis. Redox status was measured in both plasma and lung tissue. Malondialdehyde and 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine levels were measured in lung tissue. Lung tissue was evaluated histologically. Acute lung injury caused significant damage in the lung tissue, which was verified histologically, with an increase in oxidative stress parameters. Exercise prevented the lung damage induced by ALI and reduced oxidative stress in the lung tissue. Diabetes did not alter the magnitude of damage done by ALI. Exercise showed a protective effect against DM and ALI in rats. The effect of DM was insignificant for the prognosis of ALI.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep089974","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T13:20:57Z","timestamp":1637500857000},"page":"42-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of aerobic exercise on lipopolysaccharide\u2010induced experimental acute lung injury in the animal model of type 1 diabetes mellitus"],"prefix":"10.1113","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-4598","authenticated-orcid":false,"given":"G\u00f6ktu\u011f","family":"\u00d6mercio\u011flu","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1609-6847","authenticated-orcid":false,"given":"F\u0131rat","family":"Akat","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"F\u0131\u00e7\u0131c\u0131lar","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Billur","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"\u00c7al\u0131\u015fkan","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine, Ankara University  Ankara Turkey"},{"name":"Department of Physiology Faculty of Medicine, Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eule","family":"K\u0131z\u0131l","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine, Ankara University  Ankara Turkey"},{"name":"Department of Histology and Embryology Faculty of Medicine, Lokman Hekim University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine, Ankara University  Ankara Turkey"},{"name":"Department of Histology and Embryology Faculty of Medicine, Kafkas University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belgin","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine, Ankara University  Ankara Turkey"},{"name":"Department of Physiology Faculty of Medicine, Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8008-6515","authenticated-orcid":false,"given":"Metin","family":"Ba\u015ftu\u011f","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Aguiree F. 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