{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:57:04Z","timestamp":1780372624698,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Are there differences in blood pressure, arterial stiffness and indices of pressure waveforms between young oral contraceptive pill\u2010using and naturally menstruating women during lower and higher hormone phases of their cycles?<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Blood pressure, arterial stiffness and indices of pressure waveforms are influenced similarly by exogenous and endogenous hormones. However, lower levels of exogenous hormones moderately increase blood pressure among oral contraceptive pill\u2010using women.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Elevations in blood pressure (BP) are understood as having a bidirectional relationship with stiffening of central and peripheral arteries. Arterial stiffness is mitigated by oestrogen, which aides in arterial vasorelaxation. To evaluate whether BP, stiffness, and pressure waveforms were different between young healthy naturally menstruating (non\u2010OCP) and oral contraceptive pill (OCP)\u2010using women, we measured brachial and aortic BPs, carotid\u2010to\u2010femoral pulse wave velocity, carotid \u03b2\u2010stiffness, elastic modulus, central augmentation index and augmentation index normalized to a heart rate of 75\u00a0bpm, and forward and backward pressure waveforms in 22 women (22 (1) years, OCP: <jats:italic>n<\/jats:italic>\u00a0=\u00a012). To assess phasic differences, women were studied during the early follicular (\u22645\u00a0days of menstruation onset) and early luteal (4 (2)\u00a0days post\u2010ovulation) phases of non\u2010OCP and compared to the placebo pill (\u22645\u00a0days of onset) and active pill (\u22645\u00a0days of highest\u2010dose active pill) phases of OCP. During the lower hormone phases, OCP users had significantly higher brachial systolic blood pressure (SBP) (119.3 (8.3) vs. 110.2 (8.3) mmHg, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and aortic SBP (104.10 (7.44) vs. 96.80 (6.39) mmHg, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) as compared to non\u2010OCP users; however, during the higher hormone phases, there were no differences in measures of brachial or aortic BP, arterial stiffness, or indices of BP waveforms between OCP and non\u2010OCP users (<jats:italic>P<\/jats:italic>\u00a0\u2265\u00a00.05). In conclusion, exogenous and endogenous hormones have similar influences on BP and arterial stiffness; however, lower levels of exogenous hormones augment both central and peripheral BPs.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep090151","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T09:54:28Z","timestamp":1645696468000},"page":"374-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Arterial stiffness and blood pressure are similar in naturally menstruating and oral contraceptive pill\u2010using women during the higher hormone phases"],"prefix":"10.1113","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4746-7540","authenticated-orcid":false,"given":"Lauren E.","family":"Eagan","sequence":"first","affiliation":[{"name":"Department of Kinesiology School of Public Health University of Maryland  College Park MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina A.","family":"Chesney","sequence":"additional","affiliation":[{"name":"Department of Kinesiology School of Public Health University of Maryland  College Park MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2845-4544","authenticated-orcid":false,"given":"Sara E.","family":"Mascone","sequence":"additional","affiliation":[{"name":"Department of Kinesiology School of Public Health University of Maryland  College Park MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-4285","authenticated-orcid":false,"given":"Sushant M.","family":"Ranadive","sequence":"additional","affiliation":[{"name":"Department of Kinesiology School of Public Health University of Maryland  College Park MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2009.009186"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00188.2018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14624"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00921.2020"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18073393"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"Fleenor B. S. &Berrones A. J.(2015).Arterial stiffness: implications and interventions. SpringerBriefs in Physiology. Cham: Springer.https:\/\/doi.org\/10.1007\/978\u20103\u2010319\u201024844\u20108_3","DOI":"10.1007\/978-3-319-24844-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.8.1925"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2008.02.020"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2017.03.011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05179"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.032011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328346a5af"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657546"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328364ca4c"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613958"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12666"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2310\/6650.2006.05055"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.11.083"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/ab165f"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2005.04174.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00039.2018"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12080"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.130898"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002386"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007261"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq165"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-019-0228-5"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.05.007"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2007.01.008"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00443.2020"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.11.8013"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000012"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP090151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP090151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP090151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T21:37:05Z","timestamp":1692999425000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP090151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,8]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1113\/EP090151"],"URL":"https:\/\/doi.org\/10.1113\/ep090151","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,8]]},"assertion":[{"value":"2021-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}