{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:05:24Z","timestamp":1790643924712,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>New Findings<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What is the central question of this study?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>Does habitual exercise modality affect the directionality of the cerebral pressure\u2013flow relationship?<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What is the main finding and its importance?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>These data suggest the hysteresis\u2010like pattern of dynamic cerebral autoregulation appears present in long\u2010term sedentary and endurance\u2010trained individuals, but absent in resistance\u2010trained individuals. This is the first study to expand knowledge on the directional sensitivity of the cerebral pressure\u2013flow relationship to trained populations.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:sec>\n                      <jats:label\/>\n                      <jats:p>\n                        Evidence suggests the cerebrovasculature may be more efficient at dampening cerebral blood flow (CBF) variations when mean arterial pressure (MAP) transiently increases, compared to when it decreases. Despite divergent MAP and CBF responses to acute endurance and resistance training, the long\u2010term impact of habitual exercise modality on the directionality of dynamic cerebral autoregulation (dCA) is currently unknown. Thirty\u2010six young healthy participants (sedentary (\n                        <jats:italic>n<\/jats:italic>\n                        \u00a0=\u00a012), endurance\u2010trained (\n                        <jats:italic>n<\/jats:italic>\n                        \u00a0=\u00a012), and resistance\u2010trained (\n                        <jats:italic>n<\/jats:italic>\n                        \u00a0=\u00a012)) undertook a 5\u2010min repeated squat\u2013stand protocol at two forced MAP oscillation frequencies (0.05 and 0.10\u00a0Hz). Middle cerebral artery mean blood velocity (MCAv) and MAP were continuously monitored. We calculated absolute (\u0394MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/\u0394MAP\n                        <jats:sub>T<\/jats:sub>\n                        ) and relative (%MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/%MAP\n                        <jats:sub>T<\/jats:sub>\n                        ) changes in MCAv and MAP with respect to the transition time intervals of both variables to compute a time\u2010adjusted ratio in each MAP direction, averaged over the 5\u2010min repeated squat\u2013stand protocols. At 0.10\u00a0Hz repeated squat\u2013stands, \u0394MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/\u0394MAP\n                        <jats:sub>T<\/jats:sub>\n                        and %MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/%MAP\n                        <jats:sub>T<\/jats:sub>\n                        were lower when MAP increased compared with when MAP decreased for sedentary (\u0394MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/\u0394MAP\n                        <jats:sub>T<\/jats:sub>\n                        :\n                        <jats:italic>P\u00a0<\/jats:italic>\n                        =\u00a00.032; %MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/%MAP\n                        <jats:sub>T<\/jats:sub>\n                        :\n                        <jats:italic>P\u00a0<\/jats:italic>\n                        =\u00a00.040) and endurance\u2010trained individuals (\u0394MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/\u0394MAP\n                        <jats:sub>T<\/jats:sub>\n                        :\n                        <jats:italic>P\u00a0<\/jats:italic>\n                        =\u00a00.012; %MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/%MAP\n                        <jats:sub>T<\/jats:sub>\n                        <jats:italic>P\u00a0<\/jats:italic>\n                        =\u00a00.007), but not in the resistance\u2010trained individuals (\u0394MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/\u0394MAP\n                        <jats:sub>T<\/jats:sub>\n                        :\n                        <jats:italic>P\u00a0<\/jats:italic>\n                        =\u00a00.512; %MCAv\n                        <jats:sub>T<\/jats:sub>\n                        \/%MAP\n                        <jats:sub>T<\/jats:sub>\n                        <jats:italic>P\u00a0<\/jats:italic>\n                        =\u00a00.666). At 0.05\u00a0Hz repeated squat\u2013stands, time\u2010adjusted ratios were similar for all groups (all\n                        <jats:italic>P\u00a0<\/jats:italic>\n                        &gt;\u00a00.605). These findings suggest exercise training modality does influence the directionality of the cerebral pressure\u2013flow relationship and support the presence of a hysteresis\u2010like pattern during 0.10\u00a0Hz repeated squat\u2013stands in sedentary and endurance\u2010trained participants, but not in resistance\u2010trained individuals. In future studies, assessment of elite endurance and resistance training habits may further elucidate modality\u2010dependent discrepancies on directional dCA measurements.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1113\/ep090159","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T12:14:28Z","timestamp":1645791268000},"page":"299-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Directional sensitivity of the cerebral pressure\u2013flow relationship in young healthy individuals trained in endurance and resistance exercise"],"prefix":"10.1113","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2300-7403","authenticated-orcid":false,"given":"Marc\u2010Antoine","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Kinesiology Faculty of Medicine Universit\u00e9 Laval  Qu\u00e9bec Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5440-2804","authenticated-orcid":false,"given":"Lawrence","family":"Labrecque","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Faculty of Medicine Universit\u00e9 Laval  Qu\u00e9bec Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-519X","authenticated-orcid":false,"given":"Blake G.","family":"Perry","sequence":"additional","affiliation":[{"name":"School of Health Sciences Massey University  Wellington New Zealand"},{"name":"School of Sport Exercise and Nutrition Massey University  Wellington New 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