{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:17:19Z","timestamp":1779214639128,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL129677\u201003"],"award-info":[{"award-number":["HL129677\u201003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL138133\u201003"],"award-info":[{"award-number":["HL138133\u201003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL093238\u201007"],"award-info":[{"award-number":["HL093238\u201007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\"><jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p><jats:p>Are sensory nerve\u2010mediated vasodilatation and the NO\u2010dependent contribution to that response attenuated in the cutaneous microvasculature of women who have had preeclampsia?<\/jats:p><\/jats:list-item><jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p><jats:p>Women who have had preeclampsia demonstrate attenuated microvascular endothelium\u2010dependent dilatation compared to women with a history of uncomplicated pregnancy. However, there are no differences in sensory nerve\u2010mediated vasodilatation between groups. This suggests that the neurogenic response is not altered following preeclampsia, and that the NO\u2010dependent vasodilatation of the neurogenic response is not related to endothelium\u2010dependent NO\u2010mediated dilatation in these women.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Women who have had preeclampsia (PE) demonstrate microvascular endothelial dysfunction, mediated in part by reduced nitric oxide (NO)\u2010dependent mechanisms. Localized heating of the skin induces a biphasic vasodilatation response: a sensory nerve\u2010mediated initial peak, followed by a sustained endothelium\u2010dependent plateau. We have previously shown that the endothelium\u2010dependent plateau is attenuated in PE. However, it is unknown if the sensory nerve\u2010mediated initial peak is similarly attenuated. Therefore, the purpose of this study was to examine the effect of PE history on sensory nerve\u2010mediated vasodilatation and the NO\u2010dependent contribution to that response. We hypothesized that PE would have an attenuated initial peak and a reduced NO\u2010dependent contribution to that response compared to women with a history of normotensive pregnancy (healthy controls, HC). Nine HC (31\u00a0\u00b1\u00a04\u00a0years) and nine PE (28\u00a0\u00b1\u00a06\u00a0years) underwent a standard local heating protocol (42\u00b0C; 0.1\u00b0C\u00a0s<jats:sup>\u20131<\/jats:sup>). Two intradermal microdialysis fibres were placed in the skin of the ventral forearm for the continuous local delivery of lactated Ringer solution alone (control) or 15\u2010mM<jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine methyl ester for nitric oxide synthase (NOS) inhibition. Red blood cell flux was measured at each site by laser Doppler flowmetry (LDF). Cutaneous vascular conductance was calculated (CVC\u00a0=\u00a0LDF\/mean arterial pressure) and normalized to maximum (%CVC<jats:sub>max<\/jats:sub>; 28\u2010mM SNP + local heat 43\u00b0C). There were no differences in the initial peak between groups (HC: 79\u00a0\u00b1\u00a08 vs. PE: 80\u00a0\u00b1\u00a010%CVC<jats:sub>max<\/jats:sub>;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.936). NOS inhibition attenuated the initial peak in both HC (57\u00a0\u00b1\u00a018% CVC<jats:sub>max<\/jats:sub>;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and PE (54\u00a0\u00b1\u00a010%CVC<jats:sub>max<\/jats:sub>;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). However, there were no differences in the NO\u2010dependent portion of the initial peak (HC: 23\u00a0\u00b1\u00a016 vs. PE: 24\u00a0\u00b1\u00a09%;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.777). The local heating plateau (HC: 99\u00a0\u00b1\u00a04 vs. PE: 88\u00a0\u00b1\u00a07%CVC<jats:sub>max<\/jats:sub>;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and NO contribution to the plateau (HC: 31\u00a0\u00b1\u00a09 vs. PE: 17\u00a0\u00b1\u00a014%;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) were attenuated in PE. There was no relation between NO\u2010dependent dilatation in the initial peak and NO\u2010dependent dilatation in the plateau across groups (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.005;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.943). Women who have had PE demonstrate attenuated microvascular endothelium\u2010dependent dilatation. However, there are no differences in sensory nerve\u2010mediated vasodilatation following PE, suggesting that the NO\u2010dependent vasodilatation of the neurogenic response is not related to endothelium\u2010dependent NO\u2010mediated dilatation in these women.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep090177","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T05:49:20Z","timestamp":1640670560000},"page":"175-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Women with a history of preeclampsia have preserved sensory nerve\u2010mediated dilatation in the cutaneous microvasculature"],"prefix":"10.1113","volume":"107","author":[{"given":"Michael","family":"Pyevich","sequence":"first","affiliation":[{"name":"Department of Health and Human Physiology University of Iowa Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lacy M","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Pennsylvania State University University Park PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-3879","authenticated-orcid":false,"given":"Anna E.","family":"Stanhewicz","sequence":"additional","affiliation":[{"name":"Department of Health and Human Physiology University of Iowa Iowa City IA 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