{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T01:47:38Z","timestamp":1779241658152,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H03998"],"award-info":[{"award-number":["19H03998"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K23297"],"award-info":[{"award-number":["20K23297"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03479"],"award-info":[{"award-number":["22H03479"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Increased work of breathing and the accumulation of metabolites have neural and cardiovascular consequences through a respiratory muscle\u2010induced metaboreflex. The influence of the respiratory muscle\u2010induced metaboreflex on splanchnic blood flow in humans remains unknown.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Coeliac artery blood flow decreased gradually during inspiratory resistive breathing, accompanied by a progressive increase in arterial blood pressure. It is possible that the respiratory muscle\u2010induced metaboreflex contributes to splanchnic blood flow regulation.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to clarify the effect of increasing inspiratory muscle work on coeliac artery blood flow. Eleven healthy young males completed the study. The subjects performed voluntary hyperventilation with or without inspiratory resistance (loading or non\u2010loading trial; tidal volume of 40% of vital capacity and breathing frequency of 20\u00a0breaths\/min). The loading trial was conducted with inspiratory resistance (40% of maximal inspiratory pressure) and was terminated when the subjects could no longer maintain the target tidal volume or breathing frequency. The non\u2010loading trial was conducted without inspiratory resistance and was of the same duration as the loading trial. Arterial blood pressure was recorded using finger photoplethysmography, and coeliac artery blood flow was measured using Doppler ultrasound. Mean arterial blood pressure increased gradually during the loading trial (mean\u00a0\u00b1\u00a0SD; from 89.0\u00a0\u00b1\u00a010.8 to 103.9\u00a0\u00b1\u00a017.3\u00a0mmHg) but not in the non\u2010loading trial (from 88.7\u00a0\u00b1\u00a05.9 to 90.4\u00a0\u00b1\u00a09.9\u00a0mmHg). Coeliac artery blood flow and coeliac vascular conductance decreased gradually during the loading trial (from 601.2\u00a0\u00b1\u00a0155.7 to 482.6\u00a0\u00b1\u00a0149.5\u00a0mL\/min and from 6.9\u00a0\u00b1\u00a02.2 to 4.8\u00a0\u00b1\u00a01.7\u00a0mL\/min\/mmHg, respectively) but were unchanged in the non\u2010loading trial (from 630.7\u00a0\u00b1\u00a0157.1 to 635.6\u00a0\u00b1\u00a0195.7\u00a0mL\/min and from 7.1\u00a0\u00b1\u00a01.8 to 7.2\u00a0\u00b1\u00a02.9\u00a0mL\/min\/mmHg, respectively). These results show that increasing inspiratory muscle work affects splanchnic blood flow regulation, and we suggest that this might be mediated by the inspiratory muscle\u2010induced metaboreflex.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep090504","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T12:55:27Z","timestamp":1656593727000},"page":"1094-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Blood pressure and coeliac artery blood flow responses during increased inspiratory muscle work in healthy males"],"prefix":"10.1113","volume":"107","author":[{"given":"Kana","family":"Shiozawa","sequence":"first","affiliation":[{"name":"Graduate School of Medicine Nagoya University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Kashima","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Prefectural University of Hiroshima  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahiro","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Research and Development Hosei University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Ishida","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Nagoya University  Nagoya Japan"},{"name":"Research Center of Health Physical Fitness and Sports Nagoya University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7245-3496","authenticated-orcid":false,"given":"Keisho","family":"Katayama","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Nagoya University  Nagoya Japan"},{"name":"Research Center of Health Physical Fitness and Sports Nagoya University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00183.2010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.3.1285"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.166.4.518"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01826056"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.116640"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.233908"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.12.015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00790.2001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP086566"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13212"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.91491.2007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.5.1550"},{"key":"e_1_2_9_15_1","first-page":"1714","article-title":"Redistribution of visceral blood volume in upright exercise in healthy volunteers","volume":"29","author":"Froelich J. 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