{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:48:51Z","timestamp":1791924531942,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the test\u2013retest reliability of, and age\u2010related differences in, markers of skeletal muscle metabolism and microvascular function derived from the near\u2010infrared spectroscopy with vascular occlusion test (NIRS\u2010VOT) in younger women (YW) and middle\u2010aged and older women (MAOW). Seventeen YW (age 23\u00a0\u00b1\u00a04\u00a0years) and 17 MAOW (age 59\u00a0\u00b1\u00a08\u00a0years) completed this study. Participants completed identical experimental visits separated by \u223c4\u00a0weeks during which the NIRS\u2010VOT was used to quantify the occlusion slope, minimum and maximum tissue saturation, ischaemic index, reperfusion magnitude, the reperfusion and 10\u2010s reperfusion slopes (slope 2 and slope 2<jats:sub>10\u2010s<\/jats:sub>), time to max tissue saturation, and area under the reperfusion curve using the local tissue oxygen saturation signal. Except for slope 2<jats:sub>10\u2010s<\/jats:sub> (intraclass correlation coefficient (ICC)\u00a0=\u00a00.37; coefficient of variation (CV)\u00a0=\u00a031%), time to max tissue saturation (ICC\u00a0=\u00a00.21), and ischaemic index (ICC\u00a0=\u00a00.37) for MAOW, all of the NIRS variables demonstrated good to excellent relative reliability for the YW (ICCs\u00a0=\u00a00.74\u20130.86) and the MAOW (ICCs\u00a0=\u00a00.51\u20130.87), with CVs of 2\u201321% and 2\u201322%, respectively. The occlusion slope was significantly lower, indicating accelerated deoxygenation, while maximum tissue saturation, reperfusion magnitude, and ischaemic index were significantly higher in YW versus MAOW. No other group differences were found. In conclusion, our data support the use of the NIRS\u2010VOT as a simple, reliable, non\u2010invasive technique for the assessment of peripheral skeletal muscle metabolism and microvascular function in women, with the reliability being generally greater in YW versus MAOW. Further, our data suggest that ageing is associated with lower skeletal muscle metabolism and microvascular hyperaemic responsiveness in women.<\/jats:p>","DOI":"10.1113\/ep090540","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:29:10Z","timestamp":1669296550000},"page":"123-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Metabolic and microvascular function assessed using near\u2010infrared spectroscopy with vascular occlusion in women: age differences and reliability"],"prefix":"10.1113","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2643-2904","authenticated-orcid":false,"given":"Emily M.","family":"Rogers","sequence":"first","affiliation":[{"name":"Integrative Laboratory of Applied Physiology and Lifestyle Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nile F.","family":"Banks","sequence":"additional","affiliation":[{"name":"Integrative Laboratory of Applied Physiology and Lifestyle Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-3414","authenticated-orcid":false,"given":"Nathaniel D. M.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Integrative Laboratory of Applied Physiology and Lifestyle Medicine University of Iowa  Iowa City IA USA"},{"name":"Abboud Cardiovascular Research Center University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-020-04532-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00166.2018"},{"key":"e_1_2_10_4_1","volume-title":"Social statistics","author":"Blalock H. M.","year":"1972"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2013.10.004"},{"key":"e_1_2_10_6_1","first-page":"1","article-title":"A simplified guide to determination of sample size requirements for estimating the value of intraclass correlation coefficient: A review","volume":"12","author":"Bujang M. 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