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Control animals received water (100\u00a0\u03bcl). After 7 days, the implants were removed for assessment of inflammatory, angiogenic and fibrogenic markers.<\/jats:p><jats:p>Compared with control values, NaBu treatment decreased mast cell recruitment\/activation, inflammatory enzyme activities, levels of pro\u2010inflammatory cytokines, and the proteins p65 and p50 of the nuclear factor\u2010\u03baB pathway. Angiogenesis, as determined by haemoglobin content, vascular endothelial growth factor levels and the number of blood vessels in the implant, was reduced by the treatment. In NaBu\u2010treated animals, the predominant collagen present in the abdominal fibrovascular tissue was thin collagen, whereas in control implants it was thick collagen. Transforming growth factor\u2010\u03b21 levels were also lower in implants of treated animals. Sodium butyrate downregulated the inflammatory, angiogenesis and fibrogenesis axes of the fibroproliferative tissue induced by the intraperitoneal synthetic matrix. This compound has potential to control\/regulate chronic inflammation and adverse healing processes in the abdominal cavity.<\/jats:p>","DOI":"10.1113\/ep090559","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T19:14:28Z","timestamp":1670008468000},"page":"146-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sodium butyrate attenuates peritoneal fibroproliferative process in mice"],"prefix":"10.1113","volume":"108","author":[{"given":"Marcela Guimar\u00e3es Takahashi","family":"De Lazari","sequence":"first","affiliation":[{"name":"Department of General Pathology Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-2646","authenticated-orcid":false,"given":"Celso Tarso 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