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In the present study, we examined whether the renal changes occurring post\u2010nephrectomy were accompanied by cognitive changes as well, and whether early administration of zinc supplements such as ZnSO<jats:sub>4<\/jats:sub> to uninephrectomized (UNX) rats could ameliorate the renal and cognitive changes if present. The present study included 30 adult male Wistar rats that were randomly assigned to three groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a010 per group): sham\u2010operated rats, UNX and UNX treated with ZnSO<jats:sub>4<\/jats:sub> for 20\u00a0weeks. Before termination, rats were subjected to 24\u2010h urine collection and behavioural testing with the Morris water maze and T maze tests. UNX induced significant proteinuria, renal functional, fibrotic and oxidative changes, as well as increased renal desmin expression. UNX rats also showed significant behavioural changes indicating spatial learning and memory affection, together with decreased hippocampal brain derived neurotrophic factor (BDNF) and antioxidant capacity, and increased glial fibrillary acidic protein (GFAP), nitric oxide and malondialdehyde. In addition, UNX induced significant hyperglycaemia and dyslipidaemia, as well as significant reduction in serum zinc, copper and selenium. Early administration of ZnSO<jats:sub>4<\/jats:sub> starting 1\u00a0week post\u2010nephrectomy significantly ameliorated renal and behavioural\u00a0changes, as well as hippocampal oxidative, BDNF and GFAP changes. Additionally, Zn recovered serum changes of triglycerides, cholesterol, zinc and copper. Therefore, early administration of zinc to humans undergoing nephrectomy may be of benefit and should be considered in human trials.<\/jats:p>","DOI":"10.1113\/ep090735","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:30:14Z","timestamp":1669296614000},"page":"253-267","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Possible protective effect of zinc administration on renal and cognitive changes occurring in uninephrectomized adult male Wistar rats"],"prefix":"10.1113","volume":"108","author":[{"given":"Marianne","family":"Basta","sequence":"first","affiliation":[{"name":"Department of Medical Physiology Faculty of Medicine University of Alexandria  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hend A.","family":"Yassin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine University of 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