{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T09:46:59Z","timestamp":1774172819837,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the main observation in this case?<\/jats:bold><\/jats:p>\n<jats:p>Co\u2010administration of LGD\u20104033 and MK\u2010677 increased body mass, lean mass and fat mass, while negatively impacting bone, serum lipids, liver enzymes, testosterone (total and free) and, probably, follicle\u2010stimulating hormone.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What insights does it reveal?<\/jats:bold><\/jats:p>\n<jats:p>Our cross\u2010sectional data imply that these compounds might alter intramuscular androgenic hormone and receptor concentrations along with promoting muscular strength, when compared with previously published data from trained males.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>LGD\u20104033, a selective androgen receptor modulator, and MK\u2010677, a growth hormone secretagogue, are being used increasingly amongst recreationally active demographics. However, limited data exist describing their effects on health\u2010 and androgen\u2010related biomarkers. The purpose of this case study was to determine changes in body composition and biomarkers during and after continued co\u2010administration of LGD\u20104033 and MK\u2010677. We also aimed to examine muscular strength and intramuscular androgen\u2010associated biomarkers relative to non\u2010users. A 25\u2010year\u2010old male ingested LGD\u20104033 (10\u00a0mg) and MK\u2010677 (15\u00a0mg) daily for 5\u00a0weeks. Blood and body composition metrics were obtained pre\u2010, on\u2010 and post\u2010cycle. One\u2010repetition maximum leg and bench press, in addition to intramuscular androgens and androgen receptor content, were analysed on\u2010cycle. We observed pre\u2010 to on\u2010cycle changes in body composition (body mass, +6.0%; total lean body mass, +3.1%; trunk lean body mass, +6.6%; appendicular lean body mass, +4.3%; total fat mass, +15.4%; trunk fat mass, +2.8%; and appendicular fat mass, +14.8%), bone (bone mineral content, \u22123.60%; area, \u22121.1%; and bone mineral density, \u22122.1%), serum lipid\u2010associated biomarkers (cholesterol, +14.8%; triglycerides, +39.2%; low\u2010density lipoprotein\u2013cholesterol, +40.0%; and high\u2010density lipoprotein\u2013cholesterol, \u221236.4%), liver\u2010associated biomarkers (aspartate aminotransferase, +95.8%; and alanine aminotransferase, +205.0%) and androgen\u2010associated biomarkers (free testosterone, \u221285.7%; total testosterone, \u221262.3%; and sex hormone\u2010binding globulin, \u221279.6%); however, all variables returned to pre\u2010cycle values post\u2010cycle, apart from total fat mass, appendicular fat mass, bone area, total cholesterol and low\u2010density lipoprotein\u2013cholesterol. Follicle\u2010stimulating hormone was below clinical reference values on\u2010 (1.2\u00a0IU\/L) and post\u2010cycle (1.3\u00a0IU\/L). Intramuscular androgen receptor (\u221244.6%), testosterone (+47.8%) and dihydrotestosterone (+34.4%), in addition to one\u2010repetition maximum leg press and bench press (+39.2 and +32.0%, respectively), were different in the case subject compared with non\u2010users. These data demonstrate that LGD\u20104033 and MK\u2010677 increase several body composition parameters, whilst negatively impacting bone and several serum biomarkers. Given the sparsity of data in recreationally using demographics, further research is warranted to elucidate the acute and chronic physiological effects of these anabolic agents.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep090741","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T05:19:54Z","timestamp":1666934394000},"page":"1467-1476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["LGD\u20104033 and MK\u2010677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report"],"prefix":"10.1113","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-819X","authenticated-orcid":false,"given":"Thomas D.","family":"Cardaci","sequence":"first","affiliation":[{"name":"Department of Pathology Microbiology and Immunology School of Medicine University of South Carolina  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven B.","family":"Machek","sequence":"additional","affiliation":[{"name":"Kinesiology Department College of Health Sciences and Human Services California State University  Monterey Bay California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-2341","authenticated-orcid":false,"given":"Dylan T.","family":"Wilburn","sequence":"additional","affiliation":[{"name":"Department of Health Human Performance and Recreation Baylor University  Waco Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery L.","family":"Heileson","sequence":"additional","affiliation":[{"name":"Nutrition Services Division Walter Reed National Military Medical Center  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dillon R.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Health Human Performance and Recreation Baylor University  Waco Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry P.","family":"Cintineo","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Lindenwood University  St. Charles Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9810-602X","authenticated-orcid":false,"given":"Darryn S.","family":"Willoughby","sequence":"additional","affiliation":[{"name":"School of Exercise and Sport Science University of Mary Harden\u2010Baylor  Belton Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2010.10.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20105080\u20104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9010097"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0000000000000500"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000370"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls078"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32832a3d79"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123829"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2020.1783721"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2015.09.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.10.4297"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.075424"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2019.11.02"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13316"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12185"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010019\u20101384\u20100"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(13)70055\u2010X"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443\u2010021\u201000465\u20100"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1456"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2512"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b12\u201000054"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b12\u201000885"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005\u20100572"},{"key":"e_1_2_9_25_1","volume-title":"Essentials of strength training and conditioning","author":"Haff G. 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