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However, in contrast to Piezo ion channels, evidence of ASICs as mechanically gated ion channels has not been found using conventional mechanoclamp approaches. Instead, ASICs are involved in the tether model of mechanotransduction, with the channels gated via tethering elements of extracellular matrix and intracellular cytoskeletons. Methods using substrate deformation\u2010driven neurite stretch and micropipette\u2010guided ultrasound were developed to reveal the roles of ASIC3 and ASIC1a, respectively. Here we summarize the evidence supporting the roles of ASICs in neurosensory mechanotransduction in knockout mouse models of ASIC subtypes and provide insight to further probe their roles in proprioception.<\/jats:p>","DOI":"10.1113\/ep090762","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T11:04:49Z","timestamp":1690283089000},"page":"66-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetic exploration of roles of acid\u2010sensing ion channel subtypes in neurosensory mechanotransduction including proprioception"],"prefix":"10.1113","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-1449","authenticated-orcid":false,"given":"Yi\u2010Chen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"},{"name":"The Ph.D. Program for Translational Medicine Taipei Medical 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