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However, the identities of the molecular players that mediate proprioceptive sensing are largely unknown. Here, we confirm the expression of the mechanosensitive ion channel ASIC2 in proprioceptive sensory neurons. By combining in vivo proprioception\u2010related functional tests with ex vivo electrophysiological analyses of muscle spindles, we showed that mice lacking <jats:italic>Asic2<\/jats:italic> display impairments in muscle spindle responses to stretch and motor coordination tasks. Finally, analysis of skeletons of <jats:italic>Asic2<\/jats:italic> loss\u2010of\u2010function mice revealed a specific effect on spinal alignment. Overall, we identify ASIC2 as a key component in proprioceptive sensing and a regulator of spine alignment.<\/jats:p>","DOI":"10.1113\/ep090776","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T08:50:11Z","timestamp":1679561411000},"page":"135-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment"],"prefix":"10.1113","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-4603","authenticated-orcid":false,"given":"Bavat","family":"Bornstein","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridgette","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Physiological Genomics, Biomedical Center Ludwig\u2010Maximilians\u2010University  Planegg\u2010Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian S.","family":"Passini","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Blecher","sequence":"additional","affiliation":[{"name":"Orthopedic Department Assuta Ashdod University Hospital, Ashdod, Israel, affiliated to Ben Gurion University of the Negev  Beer Sheba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Assaraf","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shamir Medical Center, Assaf HaRofeh Campus, Zeffifin, Israel, affiliated to Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Meng","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Chemical Research Support Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Brumfeld","sequence":"additional","affiliation":[{"name":"Department of Chemical Research Support Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tsoory","sequence":"additional","affiliation":[{"name":"Department of Veterinary Resources Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Physiological Genomics, Biomedical Center Ludwig\u2010Maximilians\u2010University  Planegg\u2010Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1584-6602","authenticated-orcid":false,"given":"Elazar","family":"Zelzer","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16971-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.07.073"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.07.022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.81843"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2021.01.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2652"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017279"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00006-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0448-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602812"},{"key":"e_1_2_9_12_1","first-page":"261","article-title":"Outline for the study of scoliosis","volume":"5","author":"Cobb J. 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