{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:50:39Z","timestamp":1775083839626,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["3R01HL117037\u201005S1"],"award-info":[{"award-number":["3R01HL117037\u201005S1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5R01HL117037"],"award-info":[{"award-number":["5R01HL117037"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current study was designed to test the hypotheses that (1) reducing systemic inflammation via a 12\u2010week functional electrical stimulation rowing exercise training (FESRT) prescription results in augmented pulmonary function, and (2) the magnitude of improvement in pulmonary function is inversely associated with the magnitude of systemic inflammation suppression in persons with sub\u2010acute (\u22642\u00a0years) spinal cord injury (SCI). We conducted a retrospective analysis of a randomized controlled trial (NCT#02139436). Twenty\u2010one participants were enrolled (standard of care (SOC; <jats:italic>n<\/jats:italic>\u00a0=\u00a09) or FESRT (<jats:italic>n<\/jats:italic>\u00a0=\u00a012)). The exercise prescription was three sessions\/week at 70\u201385% of peak heart rate. A two\u2010way analysis of covariance and regression analysis was used to assess group differences and associations between pulmonary function, log transformed high\u2010sensitivity C\u2010reactive protein (hsCRP<jats:sub>log<\/jats:sub>) and white blood cell count (WBC). Following FESRT, clinically significant improvements in forced expiratory volume in 1\u00a0s (FEV<jats:sub>1<\/jats:sub>; 0.25 (0.08\u20130.43) vs. \u22120.06 (\u22120.26 to 0.15) litres) and forced vital capacity (0.22 (0.04\u20130.39) vs. 0.08 (\u22120.29 to 0.12) litres) were noted and systemic WBC (\u22121.45 (\u22122.48 to \u22120.50) vs. 0.41 (\u22120.74 to 1.56) \u03bcl) levels were suppressed compared to SOC (mean change (95% confidence interval); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Additionally, both \u0394hsCRP<jats:sub>log<\/jats:sub> and \u0394WBC were predictors of \u0394FEV<jats:sub>1<\/jats:sub> (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.89 and 0.43, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Twelve weeks of FESRT improves pulmonary function and reduces WBC in persons with sub\u2010acute SCI. The potency of FESRT to augment pulmonary function may depend on adequate suppression of systemic inflammation.<\/jats:p>","DOI":"10.1113\/ep090785","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T19:27:27Z","timestamp":1673292447000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Improved pulmonary function is associated with reduced inflammation after hybrid whole\u2010body exercise training in persons with spinal cord injury"],"prefix":"10.1113","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-1376","authenticated-orcid":false,"given":"Brandon A.","family":"Yates","sequence":"first","affiliation":[{"name":"Cardiovascular Research Laboratory Spaulding Rehabilitation Hospital  Cambridge MA USA"},{"name":"Department of Physical Medicine and Rehabilitation Harvard Medical School  Boston MA USA"},{"name":"Indiana Center for Musculoskeletal Health Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Brown","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine Unit and Department of Medicine Massachusetts General Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen","family":"Picard","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Laboratory Spaulding Rehabilitation Hospital  Cambridge MA USA"},{"name":"Department of Physical Medicine and Rehabilitation Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Andrew","family":"Taylor","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Laboratory Spaulding Rehabilitation Hospital  Cambridge MA USA"},{"name":"Department of Physical Medicine and Rehabilitation Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262864"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1310\/sci2201-71"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2020.1752976"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181e52e69"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000046"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113143"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01550"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210429200"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2006.11753898"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.228"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1179\/2045772315Y.0000000045"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0459-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2022.2048910"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.08.024"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.3.725"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3102131"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.76"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199102000-00007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2016.4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31802f0247"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.07.006"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2020.1773029"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00164.2004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.02.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000880"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.11.003"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00729.2002"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2008.02.018"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2015.07.001"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.044"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-020-04536-w"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000564"}],"container-title":["Experimental 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