{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:23:55Z","timestamp":1792873435056,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL141205"],"award-info":[{"award-number":["R01 HL141205"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this case report was to evaluate in vivo endothelial function and nitric oxide (NO)\u2010dependent vasodilatation before and after the cessation of long\u2010term (11\u201312 years) fourth\u2010generation oral contraceptive pill (OCP) use in one young, healthy and premenopausal woman. This retrospective analysis includes data from six experimental visits: three visits during months\u00a0133\u2013144 of fourth\u2010generation OCP use and three visits 19\u201322\u00a0months after OCP cessation. Endothelium\u2010dependent and NO\u2010dependent vasodilatation were assessed in the cutaneous microvasculature using laser\u2010Doppler flowmetry, a rapid local heating protocol (39\u00b0C, 0.1\u00b0C\/s) and pharmacological perfusion through intradermal microdialysis fibres. The participant had consistent medical history and lifestyle behaviours throughout both hormonal exposures. Data are presented as the mean\u00a0(SD). Endothelium\u2010dependent vasodilatation was 42\u00a0(10)% of site\u2010specific maximal cutaneous vascular conductance (CVC<jats:sub>max<\/jats:sub>) during OCP use and 63\u00a0(10)%CVC<jats:sub>max<\/jats:sub> after OCP cessation (49% increase). Nitric oxide\u2010dependent vasodilatation was 70\u00a0(5)% contribution of NO during OCP use and 60 (15)%NO after OCP cessation (15% reduction). Baseline blood flow was greater after OCP cessation, but maximal blood flow was reduced. Data from this case report support a substantial increase in cutaneous microvascular endothelial function assessed via local heating after cessation of long\u2010term use of a fourth\u2010generation OCP, which does not appear to be attributable to increased NO bioavailability. Overall, these data suggest an improvement in endothelial and microvascular function after the cessation of long\u2010term use of a fourth\u2010generation OCP.<\/jats:p>","DOI":"10.1113\/ep090861","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T09:44:31Z","timestamp":1669801471000},"page":"5-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Microvascular endothelial function following cessation of long\u2010term oral contraceptive pill use: A case report"],"prefix":"10.1113","volume":"108","author":[{"given":"Casey G.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Stanhewicz","sequence":"additional","affiliation":[{"name":"Department of Health and Human Physiology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences School of Public Health Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Georgia State University  Atlanta Georgia 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