{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:09:12Z","timestamp":1747188552916,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL118154","HL007936"],"award-info":[{"award-number":["HL118154","HL007936"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Platelet activation may contribute to age\u2010related cerebrovascular dysfunction by interacting with the endothelial cells that regulate the response to vasodilatory stimuli. This study evaluated the relationship between a platelet inhibitor, prostacyclin, and cerebrovascular reactivity (CVR) in healthy young (<jats:italic>n<\/jats:italic>\u00a0=\u00a035; 25\u00a0\u00b1\u00a04\u00a0years; 17 women, 18 men) and older (<jats:italic>n<\/jats:italic>\u00a0=\u00a012; 62\u00a0\u00b1\u00a02\u00a0years; 8 women, 4 men) adults, who were not daily aspirin users, before and after cyclooxygenase inhibition. Prostacyclin was determined by levels of 6\u2010keto\u2010prostaglandin F1\u03b1 (6\u2010keto PGF1\u03b1)\u00a0in the blood. CVR was assessed by measuring the middle cerebral artery blood velocity response to hypercapnia using transcranial Doppler ultrasound before (CON) and 90\u00a0min after cyclooxygenase inhibition with indomethacin (INDO). In young adults, there were no associations between prostacyclin and middle cerebral artery CVR during CON (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.14, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.415) or INDO (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.27, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.118). In older adults, associations between prostacyclin and middle cerebral artery CVR during CON (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.53, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.075) or INDO (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u20130.45, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.136) did not reach the threshold for significance. We also evaluated the relationship between prostacyclin and the change in CVR between conditions (\u0394CVR). We found no association between \u0394CVR and prostacyclin in young adults (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.27, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.110); however, in older adults, those with higher baseline prostacyclin levels demonstrated significantly greater \u0394CVR (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u20130.74, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). In conclusion, older adults with higher serum prostacyclin, a platelet inhibitor, may rely more on cyclooxygenase products for cerebrovascular reactivity to hypercapnia.<\/jats:p>","DOI":"10.1113\/ep090903","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T08:50:36Z","timestamp":1683881436000},"page":"1047-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between serum prostacyclin and cerebrovascular reactivity in healthy young and older adults"],"prefix":"10.1113","volume":"108","author":[{"given":"Adam T.","family":"Corkery","sequence":"first","affiliation":[{"name":"Bruno Balke Biodynamics Laboratory, Department of Kinesiology University of Wisconsin Madison  Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-3978","authenticated-orcid":false,"given":"Kathleen 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