{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:05:18Z","timestamp":1792623918837,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","award":["21\u2010R148\u2010A9883\u201022190"],"award-info":[{"award-number":["21\u2010R148\u2010A9883\u201022190"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004102","name":"Laerdal Foundation for Acute Medicine","doi-asserted-by":"publisher","award":["3374"],"award-info":[{"award-number":["3374"]}],"id":[{"id":"10.13039\/501100004102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Animal models of cardiovascular disease are often evaluated by invasive instrumentation for phenotyping. As no consensus exists, both open\u2010 and closed\u2010chest approaches are used, which might compromise rigour and reproducibility in preclinical research. We aimed to quantify the cardiopulmonary changes induced by sternotomy and pericardiotomy in a large animal model. Seven pigs were anaesthetized, mechanically ventilated and evaluated by right heart catheterization and bi\u2010ventricular pressure\u2013volume loop recordings at baseline and after sternotomy and pericardiotomy. Data were compared by ANOVA or the Friedmann test where appropriate, with post\u2010hoc analyses to control for multiple comparisons. Sternotomy and pericardiotomy caused reductions in mean systemic (\u221212\u00a0\u00b1\u00a011\u00a0mmHg, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.027) and pulmonary pressures (\u22124\u00a0\u00b1\u00a03\u00a0mmHg, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and airway pressures. Cardiac output decreased non\u2010significantly (\u22121329\u00a0\u00b1\u00a01762\u00a0ml\/min, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.052). Left ventricular afterload decreased, with an increase in ejection fraction (+9\u00a0\u00b1\u00a07%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.027) and coupling. No changes were observed in right ventricular systolic function or arterial blood gases. In conclusion, open\u2010 versus closed\u2010chest approaches to invasive cardiovascular phenotyping cause a systematic difference in key haemodynamic variables. Researchers should adopt the most appropriate approach to ensure rigour and reproducibility in preclinical cardiovascular research.<\/jats:p>","DOI":"10.1113\/ep090919","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T12:01:26Z","timestamp":1678363286000},"page":"762-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of sternotomy and pericardiotomy on cardiopulmonary haemodynamics in a large animal model"],"prefix":"10.1113","volume":"108","author":[{"given":"Mathilde Emilie","family":"Kirk","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Tang","family":"Merit","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Moeslund","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiac, Lung and Vascular Surgery Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Juel","family":"Dragsbaek","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Valentin","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-260X","authenticated-orcid":false,"given":"Mads Dam","family":"Lyhne","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Anaesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt-20-400"},{"issue":"5","key":"e_1_2_9_3_1","first-page":"IV397","article-title":"Adverse hemodynamic effects and echocardiographic consequences of pericardial closure soon after sternotomy and pericardiotomy","volume":"82","author":"Angelini G. 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