{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:40:41Z","timestamp":1790188841212,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe hypoxaemia after cardiac surgery is associated with serious complications and a high risk of mortality. The purpose of this study is to investigate the independent risk factors of severe postoperative hypoxaemia in patients with acute Stanford type A aortic dissection. We collected 77 patients with acute Stanford type A aortic dissection who underwent surgical treatment. The primary outcome was severe postoperative hypoxaemia (PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>\u00a0\u2264\u00a0100\u00a0mmHg), and a multivariate logistic regression analysis was performed to assess the independent predictors of risk for this. A mixed\u2010effects analysis of variance model and a receiver operating characteristic (ROC) curve were generated to evaluate the predictive probabilities of risk factors for severe postoperative hypoxaemia. A total of 36.4% of patients developed severe postoperative hypoxaemia. The multivariate logistic regression analysis identified high preoperative bradykinin level (odds ratio (OR)\u00a0=\u00a055.918, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and increased body mass index (BMI; OR\u00a0=\u00a01.292, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.032) as independent predictors of severe postoperative hypoxaemia in patients with acute Stanford type A aortic dissection. The mixed\u2010effect analysis of variance model and ROC curve indicated that high preoperative bradykinin level and BMI were significant predictors of severe postoperative hypoxaemia (area under the ROC curve\u00a0=\u00a00.834 and 0.764, respectively). High preoperative bradykinin levels and obesity were independent risk factors for severe postoperative hypoxaemia in patients with acute Stanford type A aortic dissection. For obese patients with high levels of bradykinin before surgery, clinicians should actively take measures to block bradykinin\u2010mediated inflammatory reactions.<\/jats:p>","DOI":"10.1113\/ep091054","type":"journal-article","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T15:44:26Z","timestamp":1679240666000},"page":"683-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High preoperative bradykinin level is a risk factor for severe postoperative hypoxaemia in acute aortic dissection surgery"],"prefix":"10.1113","volume":"108","author":[{"given":"XinLiang","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinZhang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenJian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiYang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoLong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuYong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-4084","authenticated-orcid":false,"given":"HongJia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine Key Laboratory of Medical Engineering for Cardiovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.04.021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-015-1226-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002157"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540300050033"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.07.061"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.04.32"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-019-0888-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-022-02706-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00379.2020"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.658952"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"251","article-title":"Risk factors for hypoxemia following surgical repair of acute type A aortic dissection","volume":"24","author":"Liu N.","year":"2017","journal-title":"Interactive Cardiovascular and Thoracic Surgery"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2018.05.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02686.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.21"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.10.866"},{"issue":"23","key":"e_1_2_9_17_1","first-page":"2526","article-title":"Acute respiratory distress syndrome: The Berlin Definition","volume":"307","author":"Ranieri V. M.","year":"2012","journal-title":"Jama\u2010Journal of the American Medical Association"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093992"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04802-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.01.085"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.851447"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705200"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57555"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.07.068"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-00881-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-022-01901-y"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-1428"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP091054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP091054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP091054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T13:52:46Z","timestamp":1710251566000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP091054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,19]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1113\/EP091054"],"URL":"https:\/\/doi.org\/10.1113\/ep091054","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,19]]},"assertion":[{"value":"2022-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}