{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:37Z","timestamp":1787016217979,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310110\/2019\u20100"],"award-info":[{"award-number":["310110\/2019\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Exercise augments the hypoxia\u2010induced ventilatory response in an exercise intensity\u2010dependent manner. A mutual influence of hypoxia\u2010induced peripheral chemoreflex activation and exercise\u2010induced muscle metaboreflex activation might mediate the augmentation phenomenon. However, the nature of these reflexes' integration (i.e., hyperadditive, additive or hypoadditive) remains unclear, and the coactivation effect on breathing\u2010related sensations and emotions has not been explored. Accordingly, we investigated the effect of peripheral chemoreflex and muscle metaboreflex coactivation on ventilatory variables and breathing\u2010related sensations and emotions during exercise. Fourteen healthy adults performed 2\u2010min isocapnic static handgrip, first with the non\u2010dominant hand and immediately after with the dominant hand. During the dominant hand exercise, we (a) did not manipulate either reflex (control); (b) activated the peripheral chemoreflex by hypoxia; (c) activated the muscle metaboreflex in the non\u2010dominant arm by post\u2010exercise circulatory occlusion (PECO); or (d) coactivated both reflexes by simultaneous hypoxia and PECO use. Ventilation response to coactivation of reflexes (mean\u00a0\u00b1\u00a0SD, 13\u00a0\u00b1\u00a06\u00a0l\/min) was greater than the sum of responses to separated activations of reflexes (mean\u00a0\u00b1\u00a0SD, 8\u00a0\u00b1\u00a08\u00a0l\/min,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.005). Breathing\u2010related sensory and emotional responses were similar between coactivation of reflexes and the sum of separate activations of reflexes. Thus, the peripheral chemoreflex and muscle metaboreflex integration during exercise appeared to be hyperadditive with regard to ventilation and additive with regard to breathing\u2010related sensations and emotions in healthy adults.\n                  <\/jats:p>","DOI":"10.1113\/ep091094","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T08:08:41Z","timestamp":1681114121000},"page":"932-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ventilatory response to peripheral chemoreflex and muscle metaboreflex during static handgrip in healthy humans: evidence of hyperadditive integration"],"prefix":"10.1113","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-5736","authenticated-orcid":false,"given":"Diogo Machado","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Graduate Program in Translational Medicine Federal University of S\u00e3o Paulo (Unifesp)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Ribeiro","family":"Lopes","sequence":"additional","affiliation":[{"name":"Graduate Program in Translational Medicine Federal University of S\u00e3o Paulo (Unifesp)  S\u00e3o Paulo SP Brazil"},{"name":"Paulista Association for the Development of Medicine (SPDM)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Silva","family":"Gomes","sequence":"additional","affiliation":[{"name":"Graduate Program in Translational Medicine Federal University of S\u00e3o Paulo (Unifesp)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-4729","authenticated-orcid":false,"given":"Anas","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u2018Rita Levi Montalcini\u2019 University of Torino  Torino Italy"},{"name":"Graduate Program in Pulmonary Medicine Unifesp  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0473-3706","authenticated-orcid":false,"given":"Bruno Moreira","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Translational Medicine Federal University of S\u00e3o Paulo (Unifesp)  S\u00e3o Paulo SP Brazil"},{"name":"Graduate Program in Pulmonary Medicine Unifesp  S\u00e3o Paulo SP Brazil"},{"name":"Department of Physiology Unifesp  S\u00e3o Paulo SP 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