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We tested whether the cerebral vasculature is protected against systemic blood flow fluctuation during HIIE. Fourteen healthy men (age 24 \u00b1 2 years) underwent four 4\u2010min exercises at 80\u201390% of maximal workload (<jats:italic>W<\/jats:italic><jats:sub>max<\/jats:sub>) interspaced by 3\u2010min active rest at 50\u201360% <jats:italic>W<\/jats:italic><jats:sub>max<\/jats:sub>. Transcranial Doppler measured middle cerebral artery blood velocity (CBV). Systemic haemodynamics (Modelflow) and aortic pressure (AoP, general transfer function) were estimated from an invasively recorded brachial arterial pressure waveform. Using transfer function analysis, gain and phase between AoP and CBV (0.39\u201310.0\u00a0Hz) were calculated. Stroke volume, aortic pulse pressure and pulsatile CBV increased during exercise (time effect: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001 for all), but a time\u2010domain index of aortic\u2013cerebral pulsatile transition (pulsatile CBV\/pulsatile AoP) decreased throughout the exercise bouts (time effect: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Furthermore, transfer function gain reduced, and phase increased throughout the exercise bouts (time effect: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001 for both), suggesting the attenuation and delay of pulsatile transition. The cerebral vascular conductance index (mean CBV\/mean arterial pressure; time effect: <jats:italic>P<\/jats:italic>\u00a0=\u00a00.296), an inverse index of cerebral vascular tone, did not change even though systemic vascular conductance increased during exercise (time effect: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The arterial system to the cerebral vasculature may attenuate pulsatile transition during HIIE as a defence mechanism against pulsatile fluctuation for the cerebral vasculature.<\/jats:p>","DOI":"10.1113\/ep091119","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T04:46:27Z","timestamp":1686631587000},"page":"1057-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Attenuated pulsatile transition to the cerebral vasculature during high\u2010intensity interval exercise in young healthy men"],"prefix":"10.1113","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2603-0692","authenticated-orcid":false,"given":"Jun","family":"Sugawara","sequence":"first","affiliation":[{"name":"Human Informatics and Interaction Research Institute National Institute of Advanced Industrial Science and Technology  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Graduate School of Sport and Health Science Ritsumeikan University  Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-0497","authenticated-orcid":false,"given":"Hayato","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences Waseda University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels H.","family":"Secher","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Rigshospitalet, Institute for Clinical Medicine University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5297-6468","authenticated-orcid":false,"given":"Shigehiko","family":"Ogoh","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Toyo University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001387R"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1310\/tsr2004-317"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00202.2021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700381RR"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000948"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f0c9f5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90549.2008"},{"key":"e_1_2_9_11_1","volume-title":"McDonald's blood flow in arteries theoretical, experimental and clinical principles","author":"Nichols W. 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