{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:11:59Z","timestamp":1787062319304,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T00:00:00Z","timestamp":1698537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H003098"],"award-info":[{"award-number":["15H003098"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H03230"],"award-info":[{"award-number":["16H03230"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JSPS\/OF317"],"award-info":[{"award-number":["JSPS\/OF317"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypoxia has the potential to impair cognitive function; however, it is still uncertain which cognitive domains are adversely affected. We examined the effects of acute hypoxia (\u223c7\u00a0h) on central executive (Go\/No\u2010Go) and non\u2010executive (memory) tasks and the extent to which impairment was potentially related to regional cerebral blood flow and oxygen delivery (CDO\n                    <jats:sub>2<\/jats:sub>\n                    ). Twelve male participants performed cognitive tasks following 0, 2, 4 and 6\u00a0h of passive exposure to both normoxia and hypoxia (12% O\n                    <jats:sub>2<\/jats:sub>\n                    ), in a randomized block cross\u2010over single\u2010blinded design. Middle cerebral artery (MCA) and posterior cerebral artery (PCA) blood velocities and corresponding CDO\n                    <jats:sub>2<\/jats:sub>\n                    were determined using bilateral transcranial Doppler ultrasound. In hypoxia, MCA DO\n                    <jats:sub>2<\/jats:sub>\n                    was reduced during the Go\/No\u2010Go task (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.010 vs. normoxia, main effect), and PCA DO\n                    <jats:sub>2<\/jats:sub>\n                    was attenuated during memorization (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.005 vs. normoxia) and recall components (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.002 vs. normoxia) in the memory task. The accuracy of the memory task was also impaired in hypoxia (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.049 vs. normoxia). In contrast, hypoxia failed to alter reaction time (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.19 vs. normoxia) or accuracy (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.20 vs. normoxia) during the Go\/No\u2010Go task, indicating that selective attention and response inhibition were preserved. Hypoxia did not affect cerebral blood flow or corresponding CDO\n                    <jats:sub>2<\/jats:sub>\n                    responses to cognitive activity (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a00.05 vs. normoxia). Collectively, these findings highlight the differential sensitivity of cognitive domains, with memory being selectively vulnerable in hypoxia.\n                  <\/jats:p>","DOI":"10.1113\/ep091245","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T12:13:51Z","timestamp":1698581631000},"page":"1516-1530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acute hypoxia impairs posterior cerebral bioenergetics and memory in man"],"prefix":"10.1113","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0896-7008","authenticated-orcid":false,"given":"Soichi","family":"Ando","sequence":"first","affiliation":[{"name":"Graduate School of Informatics and Engineering The University of Electro\u2010Communications  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-0497","authenticated-orcid":false,"given":"Hayato","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"},{"name":"Faculty of Sports Science Waseda University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-7038","authenticated-orcid":false,"given":"Benjamin S.","family":"Stacey","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8992-0916","authenticated-orcid":false,"given":"Takuro","family":"Washio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Toyo University  Kawagoe Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-0616","authenticated-orcid":false,"given":"Thomas S.","family":"Owens","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Calverley","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1515-0672","authenticated-orcid":false,"given":"Lewis","family":"Fall","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd 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