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However, the underlying mechanisms are poorly understood, and there is an unmet need to develop new therapies to treat this condition. Using a novel object recognition test, we show that recognition memory impairments in D2.<jats:italic>mdx<\/jats:italic> mice are completely prevented by daily treatment with the new adiponectin receptor agonist ALY688 from day 7 to 28 of age. In comparison to age\u2010matched wild\u2010type mice, untreated D2.<jats:italic>mdx<\/jats:italic> mice demonstrated lower hippocampal mitochondrial respiration (carbohydrate substrate), greater serum interleukin\u20106 cytokine content and greater hippocampal total tau and Raptor protein contents. Each of these measures was partly or fully preserved after treatment with ALY688. Collectively, these results indicate that adiponectin receptor agonism improves recognition memory in young D2.<jats:italic>mdx<\/jats:italic> mice.<\/jats:p>","DOI":"10.1113\/ep091274","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T04:29:39Z","timestamp":1688704179000},"page":"1108-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Memory impairment in the D2.<i>mdx<\/i> mouse model of Duchenne muscular dystrophy is prevented by the adiponectin receptor agonist ALY688"],"prefix":"10.1113","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7895-0271","authenticated-orcid":false,"given":"Catherine A.","family":"Bellissimo","sequence":"first","affiliation":[{"name":"School of Kinesiology &amp; Health Science York University Toronto ON Canada"},{"name":"Muscle Health Research Centre York University Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura N.","family":"Castellani","sequence":"additional","affiliation":[{"name":"School of Kinesiology &amp; Health Science York University Toronto ON Canada"},{"name":"Muscle Health Research Centre York University Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Finch","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Brock University St Catharines ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayoorey","family":"Murugathasan","sequence":"additional","affiliation":[{"name":"School of Kinesiology &amp; Health Science York University Toronto ON Canada"},{"name":"Muscle Health Research Centre York University Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam","family":"Gandhi","sequence":"additional","affiliation":[{"name":"School of Kinesiology &amp; Health Science York University Toronto ON Canada"},{"name":"Muscle Health Research Centre York University Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Muscle Health Research Centre York University Toronto Canada"},{"name":"Department of Biology York University Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Abdul\u2010Sater","sequence":"additional","affiliation":[{"name":"School of Kinesiology &amp; Health Science York University Toronto ON Canada"},{"name":"Muscle Health Research Centre York University Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E. 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