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C57BL\/6J mice were randomized into one of four experimental groups at age 12\u00a0weeks: uninjured control, VML untreated (VML), low\u2010resistance wheel running (VML\u2010LR) and high\u2010resistance wheel running (VML\u2010HR). All mice, excluding the uninjured, were subject to a unilateral VML injury to the plantar flexor muscles and wheel running began 3\u00a0days post\u2010VML. At 8\u00a0weeks post\u2010VML, peak isometric torque was greater in uninjured compared to all VML\u2010injured groups, but both VML\u2010LR and VML\u2010HR had greater (\u223c32%) peak isometric torque compared to VML. All VML\u2010injured groups had less isokinetic torque compared to uninjured, and there was no statistical difference among VML, VML\u2010LR and VML\u2010HR. No differences in cumulative running distance were observed between VML\u2010LR and VML\u2010HR groups. Because adaptations in VML\u2010HR peak isometric torque were attributed to greater gastrocnemius muscle mass, atrophy\u2010 and hypertrophy\u2010related protein content and post\u2010translational modifications were explored via immunoblot; however, results were inconclusive. Permeabilized fibre bundle mitochondrial oxygen consumption was 22% greater in uninjured compared to VML, but there was no statistical difference among VML, VML\u2010LR and VML\u2010HR. Furthermore, neither wheel running group demonstrated a change in the relative protein content of the mitochondrial biogenesis transcription factor, peroxisome proliferator\u2010activated receptor \u03b3 coactivator 1\u2010\u03b1 (PGC\u20101\u03b1). These results indicate that resistance wheel running alone only has modest benefits in the VML\u2010injured muscle.<\/jats:p>","DOI":"10.1113\/ep091284","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T14:44:45Z","timestamp":1690901085000},"page":"1282-1294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury"],"prefix":"10.1113","volume":"108","author":[{"given":"Albino G.","family":"Schifino","sequence":"first","affiliation":[{"name":"Department of Kinesiology University of Georgia  Athens GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-5904","authenticated-orcid":false,"given":"Christiana J.","family":"Raymond\u2010Pope","sequence":"additional","affiliation":[{"name":"School of 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