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Studies have shown that the development of diabetic cardiomyopathy is related to disorders in mitochondrial metabolic substrates, changes in mitochondrial dynamics, an imbalance in mitochondrial Ca<jats:sup>2+<\/jats:sup> regulation, defects in the regulation of microRNAs, and mitochondrial oxidative stress. Physical activity may play a role in resistance to the development of diabetic cardiomyopathy by improving myocardial mitochondrial biogenesis, the level of autophagy and dynamic changes in fusion and division; enhancing the ability to cope with oxidative stress; and optimising the metabolic substrates of the myocardium. This paper puts forward a new idea for further understanding the specific mitochondrial mechanism of the occurrence and development of diabetic cardiomyopathy and clarifying the role of exercise\u2010mediated myocardial mitochondrial changes in the prevention and treatment of diabetic cardiomyopathy. This is expected to provide a new theoretical basis for exercise to reduce diabetic cardiomyopathy symptoms.<\/jats:p>","DOI":"10.1113\/ep091309","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:55:18Z","timestamp":1697518518000},"page":"190-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of exercise on improving myocardial mitochondrial function in decreasing diabetic cardiomyopathy"],"prefix":"10.1113","volume":"109","author":[{"given":"Feng","family":"Zhang","sequence":"first","affiliation":[{"name":"Sports Physiology Department Beijing Sport University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian jian","family":"Lin","sequence":"additional","affiliation":[{"name":"PE Teaching and Research Office University of International Relationship Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao nan","family":"Tian","sequence":"additional","affiliation":[{"name":"Sports Physiology Department Beijing Sport University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6514-7730","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Sports Physiology Department Beijing Sport University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"issue":"2017","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1092015","article-title":"Simvastatin ameliorates diabetic cardiomyopathy by attenuating oxidative stress and inflammation in rats","volume":"2017","author":"Al\u2010Rasheed N. 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