{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:35:00Z","timestamp":1788824100332,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to examine the effect of an acute bout of prolonged sitting with and without exercise breaks on cerebrovascular function in 7\u2010 to 13\u2010year\u2010old children. Forty\u2010two children and adolescents were recruited to a crossover trial, with 15 girls (mean age 10.1\u00a0\u00b1\u00a02.5\u00a0years) and 16 boys (mean age 10.5\u00a0\u00b1\u00a01.3\u00a0years) completing the two trial conditions: SIT, uninterrupted sitting for 3\u00a0h and CYCLE, 3\u00a0h of sitting interrupted hourly with a 10\u2010min moderate intensity exercise break. Cerebrovascular function was measured Pre and Post SIT and CYCLE from blood flow (), diameter, and shear rate of the internal carotid artery (ICA) at rest and in response to CO<jats:sub>2<\/jats:sub>. Blood velocity in the middle (MCA) and posterior (PCA) cerebral arteries was assessed at rest, during a neurovascular coupling task (NVC) and in response to CO<jats:sub>2<\/jats:sub>. We demonstrate that SIT but not CYCLE reduced ICA cerebrovascular reactivity to CO<jats:sub>2<\/jats:sub> (%\u0394 ICA \/\u0394 end\u2010tidal CO<jats:sub>2<\/jats:sub>: SIT: Pre 5.0\u00a0\u00b1\u00a02.4%\/mmHg to Post 3.3\u00a0\u00b1\u00a02.8%\/mmHg vs. CYCLE: Pre 4.4\u00a0\u00b1\u00a02.3%\/mmHg to Post 5.3\u00a0\u00b1\u00a03.4%\/mmHg, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) and slowed the MCA blood velocity onset response time to hypercapnia (SIT: Pre 57.2\u00a0\u00b1\u00a032.6\u00a0s to Post 76.6\u00a0\u00b1\u00a055.2\u00a0s, vs. CYCLE: Pre 64.1\u00a0\u00b1\u00a040.4\u00a0s to Post 52.3\u00a0\u00b1\u00a028.8\u00a0s, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05). There were no changes in NVC. Importantly, breaking up prolonged sitting with hourly exercise breaks prevented the reductions in cerebrovascular reactivity to CO<jats:sub>2<\/jats:sub> and the slowed intracranial blood velocity onset response time to hypercapnia apparent with uninterrupted sitting in children.<\/jats:p>","DOI":"10.1113\/ep091314","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T04:44:32Z","timestamp":1695271472000},"page":"1386-1399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exercise breaks prevent attenuation in cerebrovascular function following an acute bout of uninterrupted sitting in healthy children"],"prefix":"10.1113","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-0983","authenticated-orcid":false,"given":"Christine M.","family":"Tallon","sequence":"first","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences University of British Columbia  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Nowak\u2010Fl\u00fcck","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences University of British Columbia  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-1831","authenticated-orcid":false,"given":"Mathew G.","family":"Reiger","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences University of British Columbia  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Green","sequence":"additional","affiliation":[{"name":"School of Human Science (Sport and Exercise Sciences) The University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil N.","family":"Ainslie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences University of British Columbia  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-230X","authenticated-orcid":false,"given":"Ali M.","family":"McManus","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences University of British Columbia  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-9-119"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2803"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00995.2016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00310.2018"},{"issue":"200","key":"e_1_2_9_7_1","first-page":"1","article-title":"The association between accelerometer\u2010measured patterns of sedentary time and health risk in children and youth: Results for the Canadian Health Measures Survey","volume":"13","author":"Colley R. 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