{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:56:57Z","timestamp":1789390617930,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sleep\u2010disordered breathing is a respiratory disorder commonly experienced by pregnant women. The recurrent hypoxaemic events associated with sleep\u2010disordered breathing have deleterious consequences for the mother and fetus. Adult male (but not female) rats born to dams subjected to gestational intermittent hypoxia (GIH) have a higher resting blood pressure than control animals and show behavioural\/neurodevelopmental disorders. The origin of this persistent, sex\u2010specific effect of GIH in offspring is unknown, but disruption of the neuroendocrine stress pathways is a key mechanism by which gestational stress increases disease risk in progeny. Using FosB immunolabelling as a chronic marker of neuronal activation, we determined whether GIH augments basal expression of FosB in the perikaryas of cells in the paraventricular nucleus of the hypothalamus (PVN), a key structure in the regulation of the stress response and blood pressure. From gestational day 10, female rats were subjected to GIH for 8\u00a0h\/day (light phase) until the day before delivery (gestational day 21); GIH consisted of 2\u00a0min hypoxic bouts (10.5% O\n                    <jats:sub>2<\/jats:sub>\n                    ) alternating with normoxia. Control rats were exposed to intermittent normoxia over the same period (GNX). At adulthood (10\u201315\u00a0weeks), the brains of male and female rats were harvested for FosB immunohistochemistry. In males, GIH augmented PVN FosB labelling density by 30%. Conversely, PVN FosB density in GIH females was 28% lower than that of GNX females. We conclude that GIH has persistent and sex\u2010specific impacts on the development of stress pathways, thereby offering a plausible mechanism by which GIH can disturb neural development and blood pressure homeostasis in adulthood.\n                  <\/jats:p>","DOI":"10.1113\/ep091343","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T09:16:16Z","timestamp":1693300576000},"page":"1376-1385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gestational intermittent hypoxia increases FosB\u2010immunoreactive perikaryas in the paraventricular nucleus of the hypothalamus of adult male (but not female) rats"],"prefix":"10.1113","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-2166","authenticated-orcid":false,"given":"Danuzia","family":"Ambrozio\u2010Marques","sequence":"first","affiliation":[{"name":"Research Center of the Qu\u00e9bec Heart and Lung Institute Universit\u00e9 Laval  Quebec City Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Research Center of the Qu\u00e9bec Heart and Lung Institute Universit\u00e9 Laval  Quebec City Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail B.","family":"Radcliff","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, School of Veterinary Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand L.","family":"Meza","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, School of Veterinary Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-3052","authenticated-orcid":false,"given":"Tracy L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, School of Veterinary Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1051-506X","authenticated-orcid":false,"given":"Jyoti J.","family":"Watters","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, School of Veterinary Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9686-2577","authenticated-orcid":false,"given":"Richard","family":"Kinkead","sequence":"additional","affiliation":[{"name":"Research Center of the Qu\u00e9bec Heart and Lung Institute Universit\u00e9 Laval  Quebec City Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520294209105765"},{"issue":"98","key":"e_1_2_9_3_1","article-title":"Immunohistochemistry and multiple labeling with antibodies from the same host species to study adult hippocampal neurogenesis","volume":"2015","author":"Ansorg A.","year":"2015","journal-title":"Journal of Visualized Experiments: JoVE"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30198-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201295109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.5.514"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.09.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00073.2013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116694"},{"issue":"16","key":"e_1_2_9_10_1","first-page":"01","article-title":"On the origins of sleep disordered breathing, cardiorespiratory and metabolic dysfunction: Which came first, the chicken or the egg?","volume":"601","author":"Conde S. 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