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In pregnancy, these transporters, expressed at the placental barrier, are important for delivery of nutrients to the fetus, whilst also limiting entry of potentially harmful substances, such as drugs. In the present study, RNA\u2010sequencing analysis was used to investigate expression of SLCs in the fetal (embryonic day\u00a019) rat brain, choroid plexus and placenta in untreated control animals and following maternal paracetamol treatment. In the treated group, paracetamol (15\u00a0mg\/kg) was administered to dams twice daily for 5 days (from embryonic day\u00a015 to 19). In untreated animals, overall expression of SLCs was highest in the placenta. In the paracetamol treatment group, expression of several SLCs was significantly different compared with control animals, with ion, amino acid, neurotransmitter and sugar transporters most affected. The number of SLC transcripts that changed significantly following treatment was the highest in the choroid plexus and lowest in the brain. All SLC transcripts that changed in the placenta following paracetamol treatment were downregulated. These results suggest that administration of paracetamol during pregnancy could potentially disrupt fetal nutrient homeostasis and affect brain development, resulting in major consequences for the neonate and extending into childhood.<\/jats:p>","DOI":"10.1113\/ep091442","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T04:28:16Z","timestamp":1702009696000},"page":"427-444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of paracetamol\/acetaminophen on the expression of solute carriers (SLCs) in late\u2010gestation fetal rat brain, choroid plexus and the placenta"],"prefix":"10.1113","volume":"109","author":[{"given":"Yifan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neuroscience Monash University  Melbourne Victoria 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