{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:51:19Z","timestamp":1781106679094,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traumatic brain injury (TBI) is a major cause of morbidity and mortality globally. We unveiled the diagnostic value of serum NLRP3, metalloproteinase\u20109 (MMP\u20109) and interferon\u2010\u03b3 (IFN\u2010\u03b3) levels in post\u2010craniotomy intracranial infections and hydrocephalus in patients with severe craniocerebral trauma to investigate the high risk factors for these in patients with TBI, and the serological factors predicting prognosis, which had a certain clinical predictive value. Study subjects underwent bone flap resection surgery and were categorized into the intracranial infection\/hydrocephalus\/control (without postoperative hydrocephalus or intracranial infection) groups, with their clinical data documented. Serum levels of NLRP3, MMP\u20109 and IFN\u2010\u03b3 were determined using ELISA kits, with their diagnostic efficacy on intracranial infections and hydrocephalus evaluated by receiver operating characteristic curve analysis. The independent risk factors affecting postoperative intracranial infections and hydrocephalus were analysed by logistic multifactorial regression. The remission after postoperative symptomatic treatment was counted. The intracranial infection\/control groups had significant differences in Glasgow Coma Scale (GCS) scores, opened injury, surgical time and cerebrospinal fluid leakage, whereas the hydrocephalus and control groups had marked differences in GCS scores, cerebrospinal fluid leakage and subdural effusion. Serum NLRP3, MMP\u20109 and IFN\u2010\u03b3 levels were elevated in patients with post\u2010craniotomy intracranial infections\/hydrocephalus. The area under the curve values of independent serum NLRP3, MMP\u20109, IFN\u2010\u03b3 and their combination for diagnosing postoperative intracranial infection were 0.822, 0.722, 0.734 and 0.925, respectively, and for diagnosing hydrocephalus were 0.865, 0.828, 0.782 and 0.957, respectively. Serum NLRP3, MMP\u20109 and IFN\u2010\u03b3 levels and serum NLRP3 and MMP\u20109 levels were independent risk factors influencing postoperative intracranial infection and postoperative hydrocephalus, respectively. Patients with hydrocephalus had a high remission rate after postoperative symptomatic treatment. Serum NLRP3, MMP\u20109 and IFN\u2010\u03b3 levels had high diagnostic efficacy in patients with postoperative intracranial infection and hydrocephalus, among which serum NLRP3 level played a major role.<\/jats:p>","DOI":"10.1113\/ep091463","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T15:44:05Z","timestamp":1713714245000},"page":"956-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic value of serum NLRP3, metalloproteinase\u20109 and interferon\u2010\u03b3 for postoperative hydrocephalus and intracranial infection in patients with severe craniocerebral trauma"],"prefix":"10.1113","volume":"109","author":[{"given":"Qiang","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Emergency Center The Second Affiliated Hospital of Nantong University (Nantong First People's Hospital)  Nantong Jiangsu 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