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We focussed on evaluating the magnitude of the Hoffman reflex (H\u2010reflex), a neurophysiological measure representing the capability to activate motor neurons and the timing and placement of the foot during walking. We hypothesized that weight manipulation would alter H\u2010reflex magnitude, footfall and lower body kinematics. Twenty healthy participants were recruited and subjected to various weight\u2010loading conditions. The H\u2010reflex, evoked by stimulating the tibial nerve, was assessed from the dominant leg during walking. Gait was evaluated under five conditions: body weight, 20% and 40% additional body weight, and 20% and 40% reduced body weight (via a harness). Participants walked barefoot on a treadmill under each condition, and the timing of electrical stimulation was set during the stance phase shortly after the heel strike. Results show that different weight\u2010loading conditions significantly impact the timing and placement of the foot and gait stability. Weight reduction led to a 25% decrease in double limb support time and an 11% narrowing of step width, while weight addition resulted in an increase of 9% in step width compared to body weight condition. Furthermore, swing time variability was higher for both the extreme weight conditions, while the H\u2010reflex reduced to about 45% between the extreme conditions. Finally, the H\u2010reflex showed significant main effects on variability of both stance and swing phases, indicating that muscle\u2010motor excitability might serve as feedback for enhanced regulation of gait dynamics under challenging conditions.<\/jats:p>","DOI":"10.1113\/ep091492","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:28:50Z","timestamp":1710570530000},"page":"754-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adaptive gait responses to varying weight\u2010bearing conditions: Inferences from gait dynamics and H\u2010reflex magnitude"],"prefix":"10.1113","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-5762","authenticated-orcid":false,"given":"Yong Kuk","family":"Kim","sequence":"first","affiliation":[{"name":"Laboratory for Movement Biomechanics, Institute for Biomechanics, Department of Health Sciences and Technology ETH Zurich  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