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Compelling evidence from rodent models underscores how exposure to acute intermittent hypoxia (AIH) can provide a unique medium to induce spinal plasticity in key inhibitory pathways mediating stretch reflex excitability and potentially affect spasticity. In this study, we quantify the effects of a single exposure to AIH on the stretch reflex in able\u2010bodied individuals. We hypothesized that a single sequence of AIH will increase the stretch reflex excitability of the soleus muscle during ramp\u2010and\u2010hold angular perturbations applied to the ankle joint while participants perform passive and volitionally matched contractions. Our results revealed that a single AIH exposure did not significantly change the stretch reflex excitability during both passive and active matching conditions. Furthermore, we found that able\u2010bodied individuals increased their stretch reflex response from passive to active matching conditions after both sham and AIH exposures. Together, these findings suggest that a single AIH exposure might not engage inhibitory pathways sufficiently to alter stretch reflex responses in able\u2010bodied persons. However, the generalizability of our present findings requires further examination during repetitive exposures to AIH along with potential reflex modulation during functional movements, such as overground walking.<\/jats:p>","DOI":"10.1113\/ep091531","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T06:07:45Z","timestamp":1707977265000},"page":"576-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A single sequence of intermittent hypoxia does not alter stretch reflex excitability in able\u2010bodied individuals"],"prefix":"10.1113","volume":"109","author":[{"given":"Andrew Q.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Tuthill","sequence":"additional","affiliation":[{"name":"Department of 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