{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:18:07Z","timestamp":1778746687414,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ageing results in lower exercise tolerance, manifested as decreased critical power (CP). We examined whether the age\u2010related decrease in CP occurs independently of changes in muscle mass and whether it is related to impaired vascular function. Ten older (63.1\u00a0\u00b1\u00a02.5 years) and 10 younger (24.4\u00a0\u00b1\u00a04.0 years) physically active volunteers participated. Physical activity was measured with accelerometry. Leg muscle mass was quantified with dual X\u2010ray absorptiometry. The CP and maximum power during a graded exercise test (<jats:italic>P<\/jats:italic><jats:sub>GXT<\/jats:sub>) of single\u2010leg knee\u2010extension exercise were determined over the course of four visits. During a fifth visit, vascular function of the leg was assessed with passive leg movement (PLM) hyperaemia and leg blood flow and vascular conductance during knee\u2010extension exercise at 10\u00a0W, 20\u00a0W, slightly below CP (90% CP) and <jats:italic>P<\/jats:italic><jats:sub>GXT<\/jats:sub>. Despite not differing in leg lean mass (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.901) and physical activity (e.g., steps per day, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.735), older subjects had \u223c30% lower mass\u2010specific CP (old\u00a0=\u00a03.20\u00a0\u00b1\u00a00.94\u00a0W\u00a0kg<jats:sup>\u22121<\/jats:sup> vs. young\u00a0=\u00a04.60\u00a0\u00b1\u00a00.87\u00a0W\u00a0kg<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The PLM\u2010induced hyperaemia and leg blood flow and\/or conductance were blunted in the old at 20\u00a0W, 90% CP and <jats:italic>P<\/jats:italic><jats:sub>GXT<\/jats:sub> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). When normalized for leg muscle mass, CP was strongly correlated with PLM\u2010induced hyperaemia (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.52; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and vascular conductance during knee\u2010extension exercise at 20\u00a0W (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.34; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.014) and 90% CP (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.39; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). In conclusion, the age\u2010related decline in CP is not only an issue of muscle quantity, but also of impaired muscle quality that corresponds to impaired vascular function.<\/jats:p>","DOI":"10.1113\/ep091571","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T15:18:00Z","timestamp":1699370280000},"page":"240-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vascular dysfunction and the age\u2010related decline in critical power"],"prefix":"10.1113","volume":"109","author":[{"given":"Abigail","family":"Dorff","sequence":"first","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"},{"name":"Program of Gerontology Brigham Young University  Provo Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy","family":"Bradford","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Hunsaker","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Rhees","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia K.","family":"Leach","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"},{"name":"Program of Gerontology Brigham Young University  Provo Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayson R.","family":"Gifford","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"},{"name":"Program of Gerontology Brigham Young University  Provo Utah 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