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One way of increasing PP may be by using phosphodiesterase (PDE)\u20105 inhibitors, which induce vasodilatation of vascular beds. We used a combination of clinically relevant magnetic resonance imaging (MRI) techniques to characterize the impact that tadalafil infusion has on maternal, placental and fetal circulations. At 116\u2013117 days\u2019 gestational age (dGA; term, 150\u00a0days), pregnant ewes (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) underwent fetal catheterization surgery. At 120\u2013123\u00a0dGA ewes were anaesthetized and MRI scans were performed during three acquisition windows: a basal state and then \u223c15\u201375\u00a0min (TAD 1) and \u223c75\u2013135\u00a0min (TAD 2) post maternal administration (24\u00a0mg; intravenous bolus) of tadalafil. Phase contrast MRI and T<jats:sub>2<\/jats:sub> oximetry were used to measure blood flow and oxygen delivery. Placental diffusion and PP were assessed using the Diffusion\u2010Relaxation Combined Imaging for Detailed Placental Evaluation\u2014\u2018DECIDE\u2019 technique. Uterine artery (UtA) blood flow when normalized to maternal left ventricular cardiac output (LVCO) was reduced in both TAD periods. DECIDE imaging found no impact of tadalafil on placental diffusivity or fetoplacental blood volume fraction. Maternal\u2010placental blood volume fraction was increased in the TAD 2 period. Fetal  and  were not affected by maternal tadalafil administration. Maternal tadalafil administration did not increase UtA blood flow and thus may not be an effective vasodilator at the level of the UtAs. The increased maternal\u2013placental blood volume fraction may indicate local vasodilatation of the maternal intervillous space, which may have compensated for the reduced proportion of UtA .<\/jats:p>","DOI":"10.1113\/ep091593","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T12:24:06Z","timestamp":1712924646000},"page":"980-991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Maternal tadalafil treatment does not increase uterine artery blood flow or oxygen delivery in the pregnant ewe"],"prefix":"10.1113","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-3920","authenticated-orcid":false,"given":"Jack R. 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Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-6274","authenticated-orcid":false,"given":"Ashley S.","family":"Meakin","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-9242","authenticated-orcid":false,"given":"Michael D.","family":"Wiese","sequence":"additional","affiliation":[{"name":"Centre for Pharmaceutical Innovation, UniSA: Clinical and Health Sciences University of South Australia  Adelaide South Australia 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