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Eleven\u00a0individuals aged 17\u201331 (6 females\/5 males) participated in two randomized separate visits, 1\u00a0week apart. A ramp\u2010incremental test was performed during both visits until volitional failure. Visits included no pressure (control) or LBNP at \u221240\u00a0Torr (experimental) with head\u2010up tilt at 15\u00a0degrees (females) or 30\u00a0degrees (males). Transcranial Doppler ultrasound was utilized to quantify middle cerebral artery velocity (MCAv), while symptom reports were filled out before and 0, 10, and 60\u00a0min post\u2010exertion. Ratings of exertion and overall condition followed similar trends for participants across both tests. The relative increase in MCAv was blunted during the experimental condition (8%) compared to control (24%), while a greater heart rate (17 beats\/min) was achieved during the LBNP condition (\n                    <jats:italic>P\u00a0=<\/jats:italic>\n                    \u00a00.047). Symptom severity at the 0 and 10\u00a0min\u00a0post\u2010exertion time points displayed negligible\u2010to\u2010small effect sizes between conditions (Wilcoxon's\n                    <jats:italic>r\u00a0<\/jats:italic>\n                    &lt;\u00a00.11). Symptom reporting was lower at the 60\u00a0min post\u2010exertion time point with these displaying a moderate effect size (Wilcoxon's\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.31). The combination of LBNP and tilt during supine cycling did not change the participants\u2019 subjective interpretation of the exertional test but attenuated the hyperpnia\u2010induced vasodilatory MCAv response, while also enabling participants to achieve a higher heart rate during exercise and reduced symptoms 1\u00a0h later. As this protocol is safe and feasible, further research is warranted in this area for developing PPCS treatment options.\n                  <\/jats:p>","DOI":"10.1113\/ep091677","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T13:39:29Z","timestamp":1722865169000},"page":"3055-3068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility of superimposed supine cycling and lower body negative pressure as an effective means of prolonging exercise tolerance in individuals experiencing persisting post\u2010concussive symptoms: Preliminary results"],"prefix":"10.1113","volume":"111","author":[{"given":"Raelyn","family":"Javra","sequence":"first","affiliation":[{"name":"Cerebrovascular Concussion Lab, Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Sport Injury Prevention Research Centre, Faculty of Kinesiology University of Calgary  Calgary Alberta 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