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There is no effective treatment for this condition, but based on the major contribution of inflammation, anti\u2010inflammatory strategies have been evaluated in animal models and clinical trials, with conflicting results. In COVID\u201019 ARDS patients, interleukin (IL)\u20101 and IL\u20106 receptor antagonists (IL\u20101Ra and IL\u20106Ra, kineret and tocilizumab, respectively) have shown some efficacy. Moreover, we have previously developed novel peptides modulating IL\u20101R and IL\u20106R activity (rytvela and HSJ633, respectively) while preserving immune vigilance and cytoprotective pathways. We aimed to assess the efficacy of these novel IL\u20101Ra and IL\u20106Ra, compared to commercially available drugs (kineret, tocilizumab) during the exudative phase (day 7) of bleomycin\u2010induced acute lung injury (ALI) in mice. Our results first showed that none of the IL\u20101Ra and IL\u20106Ra compounds attenuated bleomycin\u2010induced weight loss and venous  increase. Histological analyses and lung water content measurements also showed that these drugs did not improve lung injury scores or pulmonary oedema, after the bleomycin challenge. Finally, IL\u20101Ra and IL\u20106Ra failed to alleviate the inflammatory status of the mice, as indicated by cytokine levels and alveolar neutrophil infiltration. 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