{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T12:27:33Z","timestamp":1777206453866,"version":"3.51.4"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002649"],"award-info":[{"award-number":["UL1TR002649"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Young individuals with post\u2010traumatic stress disorder (PTSD) display peripheral vascular and autonomic nervous system dysfunction, two factors potentially stemming from a redox imbalance. It is currently unclear if these aforementioned factors, observed at rest, alter peripheral haemodynamic responses to exercise in this population. This study examined haemodynamic responses to handgrip exercise in young individuals with PTSD following acute antioxidant (AO) supplementation. Thirteen young individuals with PTSD (age 23\u00a0\u00b1\u00a03\u00a0years), and 13 age\u2010 and sex\u2010matched controls (CTRL) participated in the study. Exercise\u2010induced changes to arm blood flow (BF), mean arterial pressure (MAP) and vascular conductance (VC) were evaluated across two workloads of rhythmic handgrip exercise (3 and 6\u00a0kg). The PTSD group participated in two visits, consuming either a placebo (PL) or AO prior to their visits. The PTSD group demonstrated significantly lower VC (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.04) across all exercise workloads (vs. CTRL), which was significantly improved following AO supplementation. In the PTSD group, AO supplementation improved VC in participants possessing the lowest VC responses to handgrip exercise, with AO supplementation significantly improving VC responses (3 and 6\u00a0kg: <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01) by blunting elevated exercise\u2010induced MAP responses (3\u00a0kg: <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01; 6\u00a0kg: <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01). Lower VC responses during handgrip exercise were improved following AO supplementation in young individuals with PTSD. AO supplementation was associated with a blunting of exercise\u2010induced MAP responses in individuals with PTSD displaying elevated MAP responses. This study revealed that young individuals with PTSD exhibit abnormal, peripherally mediated exercise responses that may be linked to a redox imbalance.<\/jats:p>","DOI":"10.1113\/ep091762","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T04:38:32Z","timestamp":1715056712000},"page":"992-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lower vascular conductance responses to handgrip exercise are improved following acute antioxidant supplementation in young individuals with post\u2010traumatic stress disorder"],"prefix":"10.1113","volume":"109","author":[{"given":"Jennifer B.","family":"Weggen","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Sciences Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley 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Kinesiology and Health Sciences Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Tuzzolo","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Sciences Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan S.","family":"Garten","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Sciences Virginia Commonwealth University  Richmond Virginia 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