{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:29:23Z","timestamp":1788330563104,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Astronauts experience combined exposure to a cephalad fluid shift and mild hypercapnia during space missions, potentially contributing to health problems. Such combined exposure may weaken dynamic cerebral autoregulation. The magnitude of cephalad fluid shift varies between individuals, and dynamic cerebral autoregulation may be affected more by greater cephalad fluid shift during combined exposure. We evaluated the dose\u2010dependent effects of head\u2010down tilt (HDT) on dynamic cerebral autoregulation during acute combined exposure to HDT and 3% CO\n                    <jats:sub>2<\/jats:sub>\n                    inhalation. Twenty healthy participants were randomly exposed to three angles of HDT (\u22125\u00b0HDT+CO\n                    <jats:sub>2<\/jats:sub>\n                    , \u221215\u00b0HDT+CO\n                    <jats:sub>2<\/jats:sub>\n                    and \u221230\u00b0HDT+CO\n                    <jats:sub>2<\/jats:sub>\n                    ). After 15\u00a0min of rest, participants inhaled room air for 10\u00a0min in a horizontal body position, then inhaled 3% CO\n                    <jats:sub>2<\/jats:sub>\n                    for 10\u00a0min under HDT. The last 6\u00a0min of data were used for analysis in each stage. Arterial pressure waveforms were obtained using finger blood pressure, and blood velocity waveforms in the middle cerebral artery were obtained using transcranial Doppler ultrasonography. Dynamic cerebral autoregulation was evaluated by transfer function analysis between waveforms. Statistical analysis was performed by two\u2010way repeated\u2010measures analysis of variance. The index of transfer function gain in the low\u2010frequency range increased significantly with \u221215\u00b0HDT+CO\n                    <jats:sub>2<\/jats:sub>\n                    and \u221230\u00b0HDT+CO\n                    <jats:sub>2<\/jats:sub>\n                    , but no changes were seen with \u22125\u00b0HDT+CO\n                    <jats:sub>2<\/jats:sub>\n                    . Phase in the low\u2010frequency range decreased significantly with all three protocols. These results of significant changes in indexes of both gain and phase during combined exposure to steep HDT (\u221215\u00b0 to \u221230\u00b0) and 3% CO\n                    <jats:sub>2<\/jats:sub>\n                    inhalation suggest weakened dynamic cerebral autoregulation with the combination of moderate cephalad fluid shift and mild hypercapnia.\n                  <\/jats:p>","DOI":"10.1113\/ep091807","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T13:47:42Z","timestamp":1725457662000},"page":"4115-4125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of the angle of head\u2010down tilt on dynamic cerebral autoregulation during combined exposure to cephalad fluid shift and mild hypercapnia"],"prefix":"10.1113","volume":"111","author":[{"given":"Tomokazu","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Social Medicine, Division of Hygiene Nihon University School of Medicine  Itabashi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yojiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Division of Hygiene Nihon University School of Medicine  Itabashi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2426-7773","authenticated-orcid":false,"given":"Ken\u2010ichi","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Division of Hygiene Nihon University School of Medicine  Itabashi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11701-020-01139-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3355-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.2.590"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15626425"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00524.2003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2012.03.019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199009000-00004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon199772103"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7089587"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3357\/AMHP.4598.2016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280318"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00390.2015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.7.1311"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00283.2021"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00778"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3357\/AMHP.4870.2017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000000158"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0070-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23286"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.06.021"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00841.2015"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/aae469"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6652-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11701-011-0302-7"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221119760"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00301"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.9790\/0853-0142933"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.44.6.939"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/20.5.615"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00651.2014"},{"key":"e_1_2_9_34_1","first-page":"48","article-title":"Transfer function analysis of gender\u2010related differences in cerebral autoregulation","volume":"41","author":"Wang X.","year":"2005","journal-title":"Biomedical Sciences Instrumentation"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08986"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.1.H233"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP091807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP091807","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP091807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:58:59Z","timestamp":1788289139000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP091807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1113\/EP091807"],"URL":"https:\/\/doi.org\/10.1113\/ep091807","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"2024-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}