{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:46:03Z","timestamp":1788896763151,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A reduction in cerebral blood flow (CBF) has been observed during spaceflight and bed rest.\u00a0We aimed to examine the magnitude and regional heterogeneity of the decrease in CBF during bed rest compared to posture changes on Earth. Seventeen participants (age, 29\u00a0\u00b1\u00a09\u00a0years, 7 females) were studied in the upright and supine posture and over 3\u00a0days of bed rest. We assessed blood flow via duplex ultrasonography in the internal carotid (ICA) and vertebral arteries (VA), and via transcranial Doppler of the middle cerebral artery (MCAv). Mean arterial pressure (MAP) and end\u2010tidal CO\n                    <jats:sub>2<\/jats:sub>\n                    () were assessed at all time points. By day 3, total CBF (1078\u00a0\u00b1\u00a0302 to 853\u00a0\u00b1\u00a0245\u00a0mL\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    <jats:italic>, P\u00a0&lt;<\/jats:italic>\n                    \u00a00.0001) and MCAv (61\u00a0\u00b1\u00a015 to 49\u00a0\u00b1\u00a012\u00a0mL\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P\u00a0&lt;<\/jats:italic>\n                    \u00a00.0001) were decreased compared to the supine posture. CBF values did not fall below the upright posture (all\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a00.05) but were lower than a calculated 24\u2010h mean baseline (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.0132). MAP remained stable (\n                    <jats:italic>P\u00a0=<\/jats:italic>\n                    \u00a00.971), as did  (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.0803), while VA blood flow decreased after 24\u00a0h and again after 72\u00a0h (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.0024). These findings indicate that CBF decreases during short\u2010term bed rest, but not below values observed in the upright posture.\n                  <\/jats:p>","DOI":"10.1113\/ep091820","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T11:49:37Z","timestamp":1737546577000},"page":"4223-4234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bed rest"],"prefix":"10.1113","volume":"111","author":[{"given":"Carmen","family":"Possnig","sequence":"first","affiliation":[{"name":"Department of Sports Science, Performance Physiology &amp; Prevention University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Marume","sequence":"additional","affiliation":[{"name":"Department of Sports Science, Performance Physiology &amp; Prevention University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Babu","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Dallas  Dallas Texas USA"},{"name":"University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3950-0523","authenticated-orcid":false,"given":"Sylvan L. 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