{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:51:35Z","timestamp":1781920295429,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Evidence reports positive effects of neck motor control and aerobic exercises (AEs) to improve pain in individuals with temporomandibular disorders (TMD) and neck pain. A single bout of exercise typically leads to an increase in pain thresholds up to 30 min post\u2010exercise, known as exercise\u2010induced hypoalgesia (EIH). Studies evaluating the effects of aerobic and neck motor control exercises on EIH in individuals with chronic neck pain and TMD are limited. Measuring treatment effects and determining the clinical significance based on exercise types and loads and EIH response can improve clinical outcomes and adherence to exercise programmes. This study was designed to determine the clinical significance of EIH after neck motor control and aerobic training in participants with TMD and neck pain. Participants between 18 and 60 years with neck pain and\/or TMD will be randomized to neck motor control or aerobic training groups. Participants will be assessed before, immediately after and 15 min after three treatment sessions within a 12\u2010week exercise programme. Assessments will include pain intensity, pressure pain thresholds and tolerance of masticatory and neck muscles, and the Global Rating of Change Scale. EIH response will be calculated in absolute and relative changes by subtracting the post\u2010 from the pre\u2010exercise values. Distribution\u2010based (e.g., effect size) and anchor\u2010based (e.g., receiver operating characteristics) methods will be performed to determine the clinical significance of EIH (minimal important difference).<\/jats:p>","DOI":"10.1113\/ep091879","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:59:10Z","timestamp":1741712350000},"page":"2777-2786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical significance of exercise\u2010induced hypoalgesia in individuals with temporomandibular disorders and neck pain: A clinical trial protocol"],"prefix":"10.1113","volume":"111","author":[{"given":"Luiz Felipe","family":"Tavares","sequence":"first","affiliation":[{"name":"Postgraduate program in Physical Therapy (PPGFT) Federal University of S\u00e3o Carlos S\u00e3o Carlos Brazil"},{"name":"University of Applied Sciences Osnabr\u00fcck Faculty of Business Management and Social Sciences Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Izabela Sobral","family":"de Oliveira\u2010Souza","sequence":"additional","affiliation":[{"name":"University of Applied Sciences Osnabr\u00fcck Faculty of Business Management and Social Sciences Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Aron","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain, Faculty of Medicine Institute of Neuroscience (IoNS) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate program in Physical Therapy (PPGFT) Federal University of S\u00e3o Carlos S\u00e3o Carlos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Bjarke","family":"Vaegter","sequence":"additional","affiliation":[{"name":"Pain Research Group, Pain Center Department of Anesthesiology and Intensive Care Medicine, University Hospital Odense, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Armijo\u2010Olivo","sequence":"additional","affiliation":[{"name":"University of Applied Sciences Osnabr\u00fcck Faculty of Business Management and Social Sciences Osnabr\u00fcck Germany"},{"name":"Faculties of Rehabilitation Medicine and Dentistry University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3182652d65"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2015.04.022"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000001799"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20140548"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2023-0104"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01150.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13671"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1191"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msksp.2020.102108"},{"key":"e_1_2_7_12_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12020242"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04675-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2020.05.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13823"},{"key":"e_1_2_7_17_1","first-page":"640","article-title":"The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta\u2010analysis","volume":"40","author":"Oliveira\u2010Souza A. 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