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A systematic review (SR) of randomized controlled trials was conducted. This SR was registered in PROSPERO (CRD42021231231). Searches were conducted in five electronic databases (MEDLINE, Embase, CINAHL, Cochrane and SCOPUS). Studies were selected if they included adults over 18 years old with neck pain. The primary outcomes were pain intensity and physical function. A meta\u2010analysis was conducted when applicable. Cochrane RoB Tool\u20102 was used to determine the risk of bias of included studies, and the certainty of the evidence was determined using the GRADE approach. Out of 4669 initial records screened, six studies published in 12 articles were included. AE was not statistically different compared to no\u2010treatment or other interventions (e.g., localized exercise or acupuncture) on pain intensity measured with a visual analogue scale (VAS) (mean difference (MD) [95%CI]: 5.16\u00a0mm [\u22126.38, 16.70]). Contrarily, strengthening exercise was better than AE for pain intensity (MD [95%CI]: \u221211.34\u00a0mm [\u221221.6, \u22121.09]) after treatment. However, when AE was combined with other therapy (strengthening exercises or acupuncture), the combined therapy was better than isolated treatments (MD [95%CI]: 7.71\u00a0mm [1.07, 14.35]). A high heterogeneity was observed between protocols, comparisons, and results (magnitudes and directions). In conclusion, AE had positive results only when combined with other therapies to reduce pain intensity and disability in patients with neck pain. However, the evidence is limited, low\u2010quality, and heterogeneous.<\/jats:p>","DOI":"10.1113\/ep091884","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T08:59:43Z","timestamp":1732006783000},"page":"2918-2944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta\u2010analysis"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7825-2676","authenticated-orcid":false,"given":"Ana lzabela Sobral","family":"de Oliveira\u2010Souza","sequence":"first","affiliation":[{"name":"Faculty of Economics and Social Sciences University of Applied Sciences Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Kempe","sequence":"additional","affiliation":[{"name":"Faculty of Economics and Social Sciences University of Applied Sciences Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Grimmelsmann","sequence":"additional","affiliation":[{"name":"Faculty of Economics and Social Sciences University of Applied Sciences Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-2599","authenticated-orcid":false,"given":"Luiz Felipe","family":"Tavares","sequence":"additional","affiliation":[{"name":"Faculty of Economics and Social Sciences University of Applied Sciences Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Postgraduate program in Physical Therapy Federal University of S\u00e3o Carlos (UFSCar)  S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Moreira","family":"De Castro\u2010Carletti","sequence":"additional","affiliation":[{"name":"Faculty of Economics and Social Sciences University of Applied Sciences Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Viegas","family":"Andrade","sequence":"additional","affiliation":[{"name":"Master's in Science of Rehabilitation Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz","family":"Dennett","sequence":"additional","affiliation":[{"name":"Geoffrey and Robyn Sperber Health Sciences Library  Edmonton Alberta Canada"},{"name":"Faculty of Rehabilitation Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Von Piekartz","sequence":"additional","affiliation":[{"name":"Faculty of Economics and Social Sciences University of Applied Sciences Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Fuentes Contreras","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Physical Therapy, Clinical Research Lab Catholic University of Maule  Talca Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-433X","authenticated-orcid":false,"given":"Susan","family":"Armijo\u2010Olivo","sequence":"additional","affiliation":[{"name":"Faculty of Economics and Social Sciences University of Applied Sciences Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Faculties of Rehabilitation Medicine and Medicine and Dentistry, Department of Physical Therapy University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v19i2.45"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91057.2008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00555.2009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181676640"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23256"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000001837"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178621"},{"key":"e_1_2_9_9_1","article-title":"Neck pain","volume":"4","author":"Binder A. 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