{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:55:58Z","timestamp":1757703358630,"version":"3.40.5"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007427","name":"Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["13222"],"award-info":[{"award-number":["13222"]}],"id":[{"id":"10.13039\/501100007427","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS), one of the most common endocrine disorders in reproductive\u2010aged women, is associated with metabolic disturbances. The present study aimed to examine changes in body weight (BW) and glucose and insulin tolerance in a prenatally\u2010androgenized (PNA) rat model of PCOS compared to control with increasing age. Pregnant rats in the experimental group were subcutaneously injected with 5\u00a0mg of free testosterone on the 20th day of pregnancy, while the control group received the solvent. Female offspring of both groups, PNA rats (rat model of PCOS) and control, were examined in terms of changes in BW, glucose and insulin tolerance at 3, 6, 12 and 20\u00a0months of age. BW at birth (6.53\u00a0\u00b1\u00a00.89\u00a0vs. 5.60\u00a0\u00b1\u00a01.18 g; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.038), 15 (25\u00a0\u00b1\u00a01.15\u00a0vs. 22.36\u00a0\u00b1\u00a03.98\u00a0g; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.019) and 30 (59.37\u00a0\u00b1\u00a010.19\u00a0vs.49.9\u00a0\u00b1\u00a09.39\u00a0g; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.022) days of age was significantly increased in the rat model of PCOS compared to control, but no significant differences were observed in BW of the rat model of PCOS compared to control at 60 (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.155) and 75 (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.932) days or at 3 (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.239), 6 (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.782), 12 (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.755) and 20 (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.092) months of age. Rat model of PCOS showed impaired glucose tolerance (IGT) at 3\u00a0months of age (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.020) and insulin resistance (IR) with increasing age (3\u201320\u00a0months of age) compared to control. Increased BW before puberty, IGT at 3\u00a0months of age and IR with increasing age were observed in our rat model of PCOS. This rat model may contribute to a better understanding of underlying mechanisms of changes in BW, IGT and IR in future studies.<\/jats:p>","DOI":"10.1113\/ep091912","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T02:39:35Z","timestamp":1732934375000},"page":"410-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impaired glucose tolerance and insulin resistance in a prenatally\u2010androgenized rat model of polycystic ovary syndrome in later life"],"prefix":"10.1113","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3769-5160","authenticated-orcid":false,"given":"Mahbanoo","family":"Farhadi\u2010Azar","sequence":"first","affiliation":[{"name":"Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Noroozzadeh","sequence":"additional","affiliation":[{"name":"Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzieh","family":"Saei Ghare Naz","sequence":"additional","affiliation":[{"name":"Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-065X","authenticated-orcid":false,"given":"Fahimeh","family":"Ramezani Tehrani","sequence":"additional","affiliation":[{"name":"Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Foundation for Research &amp; Education Excellence Vestavia Hills  AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037658"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084110"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"66","article-title":"Glucose intolerance in obese adolescents with polycystic ovary syndrome: Roles of insulin resistance and \u03b2\u2010cell dysfunction and risk of cardiovascular disease","volume":"86","author":"Arslanian S. 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