{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:01Z","timestamp":1787016181385,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The use of acute carbon monoxide inhalation (COi) and hot water immersion (HWI) are of growing interest as interventions to stimulate erythropoietin (EPO) production. However, whether EPO production is further augmented when combining these stressors and whether there are sex differences in this response are poorly understood. Therefore, we measured circulating EPO concentration in response to acute COi and HWI independently and in combination and determined whether the responses were altered by sex. Participants completed three study visits\u2014COi, HWI, and combined COi and HWI\u2014separated by 1 week in a randomized, balanced, crossover design. Renal blood velocity was measured during all interventions, and carboxyhaemoglobin was measured during and after COi. Serum samples were analysed every hour for 6\u00a0h post\u2010intervention for EPO concentration. HWI decreased renal blood velocity (46.2\u00a0cm\/s to 36.2\u00a0cm\/s) (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.0001), and COi increased carboxyhaemoglobin (1.5%\u201312.8%) (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.0001) without changing renal blood velocity (46.4\u201345.2\u00a0cm\/s) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.4456). All three interventions increased peak EPO concentration from baseline (COi: 6.02\u20139.74\u00a0mIU\/mL; HWI: 6.80\u201311.10\u00a0mIU\/mL; COi + HWI: 6.71\u201310.91\u00a0mIU\/mL) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.0048) and to the same extent (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.3505). On average, females increased EPO while males did not in response to COi (females: 6.17\u00a0mIU\/mL; males: 1.27\u00a0mIU\/mL) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.0010), HWI (females: 6.47\u00a0mIU\/mL; males: 2.14\u00a0mIU\/mL) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.0104), and COi and HWI (females: 6.65\u00a0mIU\/mL; males: 1.76\u00a0mIU\/mL) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.0256). These data emphasize that combining these interventions does not augment EPO secretion and that these interventions may work better in females.\n                  <\/jats:p>","DOI":"10.1113\/ep091923","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T03:19:35Z","timestamp":1723691975000},"page":"1782-1795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acute exposure to carbon monoxide inhalation and\/or hot water immersion transiently increases erythropoietin in females but not in males"],"prefix":"10.1113","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-8061","authenticated-orcid":false,"given":"Kaitlyn G.","family":"DiMarco","sequence":"first","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-9356","authenticated-orcid":false,"given":"Christopher L.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha E.","family":"Weiser","sequence":"additional","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma R.","family":"Matsell","sequence":"additional","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Lucernoni","sequence":"additional","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Chacon","sequence":"additional","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M. B.","family":"Grivette","sequence":"additional","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3001-1715","authenticated-orcid":false,"given":"John R.","family":"Halliwill","sequence":"additional","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-4290","authenticated-orcid":false,"given":"Andrew T.","family":"Lovering","sequence":"additional","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3459-3708","authenticated-orcid":false,"given":"Christopher T.","family":"Minson","sequence":"additional","affiliation":[{"name":"Department of Human Physiology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.32.1.54"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00756"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2002.00940.x"},{"issue":"4","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125215","article-title":"Erythropoietin in the general population: Reference ranges and clinical, biochemical and genetic correlates","volume":"10","author":"Beverborg N. 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